PIMA516144
PHD3 Monoclonal Antibody (EG188e/d5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516144-Each-of-1 | In Stock | ₹ 45,646.26 |
PIMA516144 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,646.26
GST (18%): ₹ 8,216.327
Total Price: ₹ 53,862.587
Antigen
PHD3
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
Q62630, Q9H6Z9
Gene Symbols
EGLN3
Immunogen
Partial recombinant human PHD3 protein (UniProt accession number Q9H6Z9)
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
EG188e/d5
Conjugate
Unconjugated
Gene
EGLN3
Gene Alias
2610021G09Rik; AI505553; AI648162; Egl nine homolog 3; egl nine homolog 3, mitochondrial; egl nine-like protein 3 isoform; egl-9 family hypoxia inducible factor 3; egl-9 family hypoxia-inducible factor 3; EGLN3; factor-responsive smooth muscle protein; FLJ21620; HIF prolyl hydroxylase 3; HIFP4H3; Hif-p4h-3; HIFPH3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; MGC125998; MGC125999; P4H3; Phd3; PHD-3; prolyl hydroxylase domain-containing protein 3; Sm20; SM-20
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
112399, 54702
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- The target sequence has 98% sequence homology with bovine, rat and mouse
- Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins
- Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A
- Also hydroxylates HIF2A
- Has a preference for the CODD site for both HIF1A and HIF2A
- Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site
- Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex
- Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes
- EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia
- Also hydroxylates PKM in hypoxia, limiting glycolysis
- Under normoxia, hydroxylates and regulates the stability of ADRB2
- Regulator of cardiomyocyte and neuronal apoptosis
- In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex
- In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity
- Also essential for hypoxic regulation of neutrophilic inflammation
- Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway
- Target proteins are preferentially recognized via a LXXLAP motif.
Compare Similar Items
Show Difference
Antigen: PHD3
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.05% sodium azide
Gene Accession No.: Q62630, Q9H6Z9
Gene Symbols: EGLN3
Immunogen: Partial recombinant human PHD3 protein (UniProt accession number Q9H6Z9)
Quantity: 200 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: EG188e/d5
Conjugate: Unconjugated
Gene: EGLN3
Gene Alias: 2610021G09Rik; AI505553; AI648162; Egl nine homolog 3; egl nine homolog 3, mitochondrial; egl nine-like protein 3 isoform; egl-9 family hypoxia inducible factor 3; egl-9 family hypoxia-inducible factor 3; EGLN3; factor-responsive smooth muscle protein; FLJ21620; HIF prolyl hydroxylase 3; HIFP4H3; Hif-p4h-3; HIFPH3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; MGC125998; MGC125999; P4H3; Phd3; PHD-3; prolyl hydroxylase domain-containing protein 3; Sm20; SM-20
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 112399, 54702
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
PHD3
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% sodium azide
Gene Accession No.:
Q62630, Q9H6Z9
Gene Symbols:
EGLN3
Immunogen:
Partial recombinant human PHD3 protein (UniProt accession number Q9H6Z9)
Quantity:
200 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
EG188e/d5
Conjugate:
Unconjugated
Gene:
EGLN3
Gene Alias:
2610021G09Rik; AI505553; AI648162; Egl nine homolog 3; egl nine homolog 3, mitochondrial; egl nine-like protein 3 isoform; egl-9 family hypoxia inducible factor 3; egl-9 family hypoxia-inducible factor 3; EGLN3; factor-responsive smooth muscle protein; FLJ21620; HIF prolyl hydroxylase 3; HIFP4H3; Hif-p4h-3; HIFPH3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; MGC125998; MGC125999; P4H3; Phd3; PHD-3; prolyl hydroxylase domain-containing protein 3; Sm20; SM-20
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
112399, 54702
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: APOE
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.05% sodium azide
Gene Accession No.: P02649
Gene Symbols: APOE
Immunogen: Synthetic peptide made to an internal region of human ApoE4 (within residues 100-150).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Applications: ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: 4E4
Conjugate: Unconjugated
Gene: APOE
Gene Alias: AD2; AI255918; APOE; apo-E; ApoE4; APOEA; Apolipoprotein; apolipoprotein E; apolipoprotein E3; apolipoprotein E4; Apoprotein; B2G1; BG; LDLCQ5; LPG; MGC1571
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 348
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
APOE
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% sodium azide
Gene Accession No.:
P02649
Gene Symbols:
APOE
Immunogen:
Synthetic peptide made to an internal region of human ApoE4 (within residues 100-150).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
4E4
Conjugate:
Unconjugated
Gene:
APOE
Gene Alias:
AD2; AI255918; APOE; apo-E; ApoE4; APOEA; Apolipoprotein; apolipoprotein E; apolipoprotein E3; apolipoprotein E4; Apoprotein; B2G1; BG; LDLCQ5; LPG; MGC1571
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
348
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: DUX4
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q9UBX2
Gene Symbols: Dux4
Immunogen: Synthetic peptide corresponding to the C-terminal of human DUX4.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone: P4H2
Conjugate: Unconjugated
Gene: Dux4
Gene Alias: AW822073; double homeobox; double homeobox 4; double homeobox 4-like; double homeobox B-like 1; double homeobox protein 10; Double homeobox protein 4; double homeobox protein 4/10; Dux; DUX10; Dux4; DUX4L; Duxbl; Duxbl1; EG664783; homeobox protein; RGD1311053
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 100288687
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
DUX4
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q9UBX2
Gene Symbols:
Dux4
Immunogen:
Synthetic peptide corresponding to the C-terminal of human DUX4.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone:
P4H2
Conjugate:
Unconjugated
Gene:
Dux4
Gene Alias:
AW822073; double homeobox; double homeobox 4; double homeobox 4-like; double homeobox B-like 1; double homeobox protein 10; Double homeobox protein 4; double homeobox protein 4/10; Dux; DUX10; Dux4; DUX4L; Duxbl; Duxbl1; EG664783; homeobox protein; RGD1311053
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
100288687
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: TFAM
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: tris glycine with 0.15M NaCl and 0.05% sodium azide
Gene Accession No.: P40630, Q00059, Q91ZW1
Gene Symbols: Tfam
Immunogen: Human mtTFA
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG2b κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: 18G102B2E11
Conjugate: Unconjugated
Gene: Tfam
Gene Alias: AI661103; Hmgts; Mitochondrial transcription factor 1; mitochondrial transcription factor A; MTTF1; mtTFA; TCF6; TCF-6; TCF6L1; TCF6L2; TCF6L3; Testis-specific high mobility group protein; testis-specific HMG-box protein m-tsHMG; TFAM; Transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 2; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3; transcription factor A, mitochondrial; tsHMG; TS-HMG
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 21780, 7019, 83474
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
TFAM
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
tris glycine with 0.15M NaCl and 0.05% sodium azide
Gene Accession No.:
P40630, Q00059, Q91ZW1
Gene Symbols:
Tfam
Immunogen:
Human mtTFA
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG2b κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
18G102B2E11
Conjugate:
Unconjugated
Gene:
Tfam
Gene Alias:
AI661103; Hmgts; Mitochondrial transcription factor 1; mitochondrial transcription factor A; MTTF1; mtTFA; TCF6; TCF-6; TCF6L1; TCF6L2; TCF6L3; Testis-specific high mobility group protein; testis-specific HMG-box protein m-tsHMG; TFAM; Transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 2; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3; transcription factor A, mitochondrial; tsHMG; TS-HMG
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
21780, 7019, 83474
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid