PIMA517078

FOXO1 Monoclonal Antibody (3B6), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIMA517078-Each-of-1 In Stock ₹ 42,908.34

PIMA517078 - Each of 1

₹ 42,908.34

In Stock

Quantity

1

Base Price: ₹ 42,908.34

GST (18%): ₹ 7,723.501

Total Price: ₹ 50,631.841

Antigen

FOXO1

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 0.05% sodium azide

Gene Accession No.

Q12778, Q9R1E0

Gene Symbols

FOXO1

Immunogen

Purified recombinant fragment of human FOXO1 expressed in E. Coli.

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Isotype

IgG1

Applications

ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Clone

3B6

Conjugate

Unconjugated

Gene

FOXO1

Gene Alias

Afxh; AI876417; FKH1; FKHR; Fkhr1; forkhead box O1; forkhead box O1 a; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box protein O1; forkhead box protein O1; LOW QUALITY PROTEIN: forkhead box protein O1; forkhead box protein O1A; Forkhead box protein O1-A; Forkhead in rhabdomyosarcoma; forkhead protein 1; forkhead protein FKHR; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; fox family transcription factor FoxO1a.1; FOX01A; foxhead box protein O1-A; foxo1; FOXO1A; FoxO1a.1; member of FKHR-subclass forkhead/winged helix family; zgc:153388

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

2308, 56458

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

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Description

  • MA5-17078 targets FOXO1 in ChIP, IHC, IF, and WB applications and shows reactivity with Human and Mouse samples
  • The MA5-17078 immunogen is purified recombinant fragment of human FOXO1 expressed in E
  • Coli
  • MA5-17078 detects FOXO1 which has a predicted molecular weight of approximately 69.7kDa
  • FOXO1 (FKHR, ForKHead Box 01) is a member in a subfamily of the forkhead homeotic gene family of transcription factors
  • Recent experiments have shown that FOXO1 can act as either a coactivator or a corepressor of nuclear receptor activity that is mediated through the LXXLL motif found in the carboxyl terminal region of the FKHR protein
  • Association of FOXO1 with PAX3 has been implicated in alveolar rhabdomyosarcoma
  • Recent studies link the anti-tumor activity of FOXO1, the process of autophagy and myogenic growth and differentiation
  • FOXO1 is the main target of insulin signaling that regulated the metabolic homeostasis in response to oxidative stress
  • FOXO1 binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'
  • FOXO1 is a regulator of redox balance, osteoblast numbers and controls bone mass
  • Further, FOXO1 orchestrates the endocrine function of the skeleton in regulating glucose metabolism, and suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP
  • In hepatocytes, FOXO1 promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1
  • FOXO1 is an important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIMA517078

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Antigen:
FOXO1

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.05% sodium azide

Gene Accession No.:
Q12778, Q9R1E0

Gene Symbols:
FOXO1

Immunogen:
Purified recombinant fragment of human FOXO1 expressed in E. Coli.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG1

Applications:
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Clone:
3B6

Conjugate:
Unconjugated

Gene:
FOXO1

Gene Alias:
Afxh; AI876417; FKH1; FKHR; Fkhr1; forkhead box O1; forkhead box O1 a; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box protein O1; forkhead box protein O1; LOW QUALITY PROTEIN: forkhead box protein O1; forkhead box protein O1A; Forkhead box protein O1-A; Forkhead in rhabdomyosarcoma; forkhead protein 1; forkhead protein FKHR; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; fox family transcription factor FoxO1a.1; FOX01A; foxhead box protein O1-A; foxo1; FOXO1A; FoxO1a.1; member of FKHR-subclass forkhead/winged helix family; zgc:153388

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
2308, 56458

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Img

Thermo Scientific

PIMA517079

--


Antigen:
FOXP1

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.05% sodium azide

Gene Accession No.:
Q9H334

Gene Symbols:
FOXP1

Immunogen:
Purified recombinant fragment of human FOXP1 (amino acids: 481-677) expressed in E. Coli.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1

Applications:
Flow Cytometry, Western Blot

Clone:
6E4C4

Conjugate:
Unconjugated

Gene:
FOXP1

Gene Alias:
12CC4; 3110052D19Rik; 4932443N09Rik; AI461938; AW494214; FLJ23741; Fork head related protein like B; fork head-related protein like B; forkhead box P1; forkhead box protein P1; Forkhead box protein P1 (FOXP1); Forkhead-related transcription factor 1; Foxp1; Glutamine rich factor 1; glutamine-rich factor 1; hFKH1B; HSPC215; mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551; QRF1

Host Species:
Mouse

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
27086

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Img

Thermo Scientific

PIMA517080

--


Antigen:
FZD5

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.05% sodium azide

Gene Accession No.:
Q13467

Gene Symbols:
FZD5

Immunogen:
Purified recombinant fragment of human FZD5 (amino acids:151-217) expressed in E. Coli.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1

Applications:
ELISA, Flow Cytometry, Western Blot

Clone:
2D12

Conjugate:
Unconjugated

Gene:
FZD5

Gene Alias:
C2orf31; DKFZp434E2135; frizzled 5, seven transmembrane spanning receptor; frizzled class receptor 5; frizzled family receptor 5; frizzled-5; Fz5; Fz-5; Fzd5; Fzd-5; FzE5; HFZ5; MGC129692; seven-transmembrane receptor frizzled-5; Wnt receptor

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
7855

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Img

Thermo Scientific

PIMA517082

--


Antigen:
Nucleostemin

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.05% sodium azide

Gene Accession No.:
Q8CI11, Q9BVP2

Gene Symbols:
GNL3

Immunogen:
Purified recombinant fragment of human GNL3 (amino acids: 1-226) expressed in E. Coli.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG1

Applications:
ELISA, Flow Cytometry, Western Blot

Clone:
2C8D5

Conjugate:
Unconjugated

Gene:
GNL3

Gene Alias:
C77032; E2IG3; E2-induced gene 3 protein; estradiol-induced nucleotide binding protein; G protein nucleolar 3; Gnl3; guanine nucleotide binding protein-like 3 (nucleolar); guanine nucleotide-binding protein-like 3; MGC800; NNP47; novel nucleolar protein 47; Ns; nucleolar GTP-binding protein 3; Nucleostemin

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
26354, 30877

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid