IL9R alpha Monoclonal Antibody (AH9R7), Invitrogen™

Description

• The mouse monoclonal antibody AH9R7 recognizes CD129 / IL-9R alpha, a 57 kDa type I transmembrane glycoprotein expressed at low levels by lymphocytes, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons
• Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 μm filter sterilized
• Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test
• Flow cytometry: It is recommended to use bright fluorochromes or signal multiplying detection; Functional Application: Blocking
• The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9)
• The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines
• The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses
• This gene is located at the pseudoautosomal regions of X and Y chromosomes
• Genetic studies suggested an association of this gene with the development of asthma
• Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described
• Alternatively spliced transcript variants have been found for this gene.