Caspr2 Recombinant Rabbit Monoclonal Antibody (001), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Mouse CNTNAP2/CASPR2
• This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors
• This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains
• In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site
• This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons
• This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome
• It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development
• This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.