CaMKIV Recombinant Rabbit Monoclonal Antibody (001), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Mouse CaM Kinase 4/CaMKIV
• CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF
• It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells
• The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression
• CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees
• In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects
• In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT)
• CaMKIV is encoded, along with calspermin, by the CaMKIV gene
• It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin
• The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.