Influenza H5N1 HA Recombinant Human Monoclonal Antibody (H011), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant antibodies are produced using specific genes that code for the desired antibodies
• These genes are cloned into an expression vector and expressed in vitro
• The advantages of recombinant antibodies include: better specificity, animal origin-free formulation, and more lot-to-lot consistency
• This antibody has specificity for H5N1 (A/Hubei/1/2010) HA H5N1 (A/Xinjiang/1/2006) HA1 H5N1 (A/Xinjiang/1/2006) HA H5N1 (A/bar-headed goose/Qinghai/1A/2005) HA H5N1 (A/Anhui/1/2005) HA H5N1 (A/Cambodia/S1211394/2008) HA H5N1 (A/Duck/Hong Kong/p46/97) HA H5N1 (A/Hong kong/213/2003) HA (28 Ser/Trp) H5N1 (A/chicken/India/NIV33487/06) HA H5N1 (A/Cambodia/R0405050/2007) HA H5N1 (A/whooper swan/Mongolia/244/2005) HA H5N1 (A/Egypt/N05056/2009) HA H5N1 (A/Common magpie/Hong Kong/2256/2006) HA H5N1 (A/duck/Hunan/795/2002) HA H5N1 (A/Egy
• Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA
• In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States
• The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic
• Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins
• The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release
• These proteins also elicit immune responses that prevent infection or independently reduce viral replication
• The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin
• The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups.