West Nile Virus Envelope (Domain III) (lineage 1, strain NY99) Monoclonal Antibody (03), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• This antibody has specificity for West Nile Virus (WNV) (lineage 1, strain NY99) E/Envelope (Domain III)
• West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St
• Louis encephalitis virus, yellow fever virus, and Dengue virus
• WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe
• It has rapidly spread across the United States with cases being observed in every continental state
• Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells
• The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.