CCL23 Recombinant Rabbit Monoclonal Antibody (004), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Human CCL23/MIP 3
• This gene is one of several chemokine genes clustered on the q-arm of chromosome 17
• Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes
• The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide
• This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes
• The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line
• In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1
• Alternative splicing results in multiple transcript variants that encode different isoforms.