Growth Hormone Recombinant Rabbit Monoclonal Antibody (101), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Human GH1/Growth hormone 1
• Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control
• The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17
• The five genes share a remarkably high degree of sequence identity
• Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa
• HGH is produced by the somatotroph cells in the pituitary
• It acts through binding to membrane receptors that belong to the cytokine receptor subfamily
• Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1
• It stimulates both the differentiation and proliferation of myoblasts
• It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
• Mutations or deletions in the gene lead to growth hormone deficiency and short stature.