TIM-1 Recombinant Rabbit Monoclonal Antibody (152), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Mouse TIM-1/KIM-1/HACVR
• CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail
• The endogenous ligand for CD365 is Tim-4
• In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus
• The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes
• Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity
• CD365 has also been implicated in the T cell co-stimulation
• CD365 is primarily expressed in epithelial cells
• It is also highly expressed in A549, 769-P and Caco-2 and cell lines
• CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.