LAIR1 Recombinant Rabbit Monoclonal Antibody (119), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Mouse LAIR-1/CD305
• LAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells
• Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11
• It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation
• May also play its inhibitory role independently of SH2-containing phosphatases
• Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta
• Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion
• Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells
• Inhibits the differentiation of peripheral blood precursors towards dendritic cells.