IGF2 Recombinant Rabbit Monoclonal Antibody (110), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Mouse IGF-2/IGF-II
• The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro
• IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times
• The IGFs belong to the Insulin gene family, which also contains insulin and relaxin
• The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin
• IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone
• Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor
• Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.