PIMA531610
ADAR Monoclonal Antibody (4E2E4), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA531610-Each-of-1 | In Stock | ₹ 48,127.50 |
PIMA531610 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,127.50
GST (18%): ₹ 8,662.95
Total Price: ₹ 56,790.45
Antigen
ADAR
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
P55265
Gene Symbols
Adar
Immunogen
Purified recombinant fragment of human ADAR (AA: 1085-1223) expressed in E. coli.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone
4E2E4
Conjugate
Unconjugated
Gene
Adar
Gene Alias
136 kDa double-stranded RNA-binding protein; ADA; Adar; ADAR1; Adar1p110; Adar1p150; Adenosine Deaminase; adenosine deaminase acting on RNA 1-A; adenosine deaminase RNA specific; adenosine deaminase, RNA specific; adenosine deaminase, RNA-specific; AGS6; AV242451; double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; G1P1; IFI4; IFI-4; interferon-induced protein 4; interferon-inducible protein 4; K88DSRBP; LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase; mZaADAR; P136; RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
103
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA5-31610 has been tested in indirect ELISA
- Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing.This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions
- ADAR can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing)
- Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3)
- Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities
- Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1
- Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1)
- Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1)
- Impairs HCV replication via RNA editing at multiple sites
- Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function
- Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence
- Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles
- However, high levels of ADAR1 inhibit HDV replication
- (Uniprot)
Compare Similar Items
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Antigen: ADAR
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.05% sodium azide
Gene Accession No.: P55265
Gene Symbols: Adar
Immunogen: Purified recombinant fragment of human ADAR (AA: 1085-1223) expressed in E. coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone: 4E2E4
Conjugate: Unconjugated
Gene: Adar
Gene Alias: 136 kDa double-stranded RNA-binding protein; ADA; Adar; ADAR1; Adar1p110; Adar1p150; Adenosine Deaminase; adenosine deaminase acting on RNA 1-A; adenosine deaminase RNA specific; adenosine deaminase, RNA specific; adenosine deaminase, RNA-specific; AGS6; AV242451; double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; G1P1; IFI4; IFI-4; interferon-induced protein 4; interferon-inducible protein 4; K88DSRBP; LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase; mZaADAR; P136; RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 103
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
ADAR
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% sodium azide
Gene Accession No.:
P55265
Gene Symbols:
Adar
Immunogen:
Purified recombinant fragment of human ADAR (AA: 1085-1223) expressed in E. coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone:
4E2E4
Conjugate:
Unconjugated
Gene:
Adar
Gene Alias:
136 kDa double-stranded RNA-binding protein; ADA; Adar; ADAR1; Adar1p110; Adar1p150; Adenosine Deaminase; adenosine deaminase acting on RNA 1-A; adenosine deaminase RNA specific; adenosine deaminase, RNA specific; adenosine deaminase, RNA-specific; AGS6; AV242451; double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; G1P1; IFI4; IFI-4; interferon-induced protein 4; interferon-inducible protein 4; K88DSRBP; LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase; mZaADAR; P136; RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
103
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: ADORA2A
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.05% sodium azide
Gene Accession No.: P29274
Gene Symbols: ADORA2A
Immunogen: Purified recombinant fragment of human ADORA2A (AA: 274-412) expressed in E. coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone: 6A6G11
Conjugate: Unconjugated
Gene: ADORA2A
Gene Alias: A2a receptor; A2AAR; A2aR; AA2AR; ADENO; adenosine A2a receptor; Adenosine A2a-receptor; adenosine receptor A2a; adenosine receptor subtype A2a; ADORA2; ADORA2A; Adora2l1; AR; hA2aR; RDC8; unnamed protein product
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 135
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
ADORA2A
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% sodium azide
Gene Accession No.:
P29274
Gene Symbols:
ADORA2A
Immunogen:
Purified recombinant fragment of human ADORA2A (AA: 274-412) expressed in E. coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone:
6A6G11
Conjugate:
Unconjugated
Gene:
ADORA2A
Gene Alias:
A2a receptor; A2AAR; A2aR; AA2AR; ADENO; adenosine A2a receptor; Adenosine A2a-receptor; adenosine receptor A2a; adenosine receptor subtype A2a; ADORA2; ADORA2A; Adora2l1; AR; hA2aR; RDC8; unnamed protein product
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
135
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: AEBP2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.05% sodium azide
Gene Accession No.: Q6ZN18
Gene Symbols: AEBP2
Immunogen: Purified recombinant fragment of human AEBP2 (AA: 358-495) expressed in E. coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone: 2D7B6
Conjugate: Unconjugated
Gene: AEBP2
Gene Alias: adipocyte enhancer-binding protein 2; Adipocyte enhancer-binding protein 2 homolog; AE binding protein 2; AE(adipocyte enhancer)-binding protein 2; AE-binding protein 2; AE-binding protein 2 homolog; aebp2; AU023766; B230313N05Rik; LOW QUALITY PROTEIN: zinc finger protein AEBP2; si:dkey-158p11.2; wu:fk42f11; wu:fk52h12; zgc:63755; Zinc finger protein AEBP2
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 121536
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
AEBP2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% sodium azide
Gene Accession No.:
Q6ZN18
Gene Symbols:
AEBP2
Immunogen:
Purified recombinant fragment of human AEBP2 (AA: 358-495) expressed in E. coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone:
2D7B6
Conjugate:
Unconjugated
Gene:
AEBP2
Gene Alias:
adipocyte enhancer-binding protein 2; Adipocyte enhancer-binding protein 2 homolog; AE binding protein 2; AE(adipocyte enhancer)-binding protein 2; AE-binding protein 2; AE-binding protein 2 homolog; aebp2; AU023766; B230313N05Rik; LOW QUALITY PROTEIN: zinc finger protein AEBP2; si:dkey-158p11.2; wu:fk42f11; wu:fk52h12; zgc:63755; Zinc finger protein AEBP2
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
121536
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: AEBP2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.05% sodium azide
Gene Accession No.: Q6ZN18
Gene Symbols: AEBP2
Immunogen: Purified recombinant fragment of human AEBP2 (AA: 358-495) expressed in E. coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: ELISA, Immunocytochemistry, Western Blot
Clone: 3E3C10
Conjugate: Unconjugated
Gene: AEBP2
Gene Alias: adipocyte enhancer-binding protein 2; Adipocyte enhancer-binding protein 2 homolog; AE binding protein 2; AE(adipocyte enhancer)-binding protein 2; AE-binding protein 2; AE-binding protein 2 homolog; aebp2; AU023766; B230313N05Rik; LOW QUALITY PROTEIN: zinc finger protein AEBP2; si:dkey-158p11.2; wu:fk42f11; wu:fk52h12; zgc:63755; Zinc finger protein AEBP2
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 121536
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
AEBP2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% sodium azide
Gene Accession No.:
Q6ZN18
Gene Symbols:
AEBP2
Immunogen:
Purified recombinant fragment of human AEBP2 (AA: 358-495) expressed in E. coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA, Immunocytochemistry, Western Blot
Clone:
3E3C10
Conjugate:
Unconjugated
Gene:
AEBP2
Gene Alias:
adipocyte enhancer-binding protein 2; Adipocyte enhancer-binding protein 2 homolog; AE binding protein 2; AE(adipocyte enhancer)-binding protein 2; AE-binding protein 2; AE-binding protein 2 homolog; aebp2; AU023766; B230313N05Rik; LOW QUALITY PROTEIN: zinc finger protein AEBP2; si:dkey-158p11.2; wu:fk42f11; wu:fk52h12; zgc:63755; Zinc finger protein AEBP2
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
121536
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid