PIMA532007
Acetyl-P53 (Lys370) Recombinant Rabbit Monoclonal Antibody (SR40-09), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532007-Each-of-1 | In Stock | ₹ 45,646.26 |
PIMA532007 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,646.26
GST (18%): ₹ 8,216.327
Total Price: ₹ 53,862.587
Antigen
Acetyl-P53 (Lys370)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P02340, P04637, P10361
Gene Symbols
Tp53, Trp53
Immunogen
Synthetic peptide within Human p53 aa 343-392
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot, Western Blot
Clone
SR40-09
Conjugate
Unconjugated
Gene
Tp53
Gene Alias
Antigen NY-CO-13, bbl, BCC7, bfy, bhy, cellular tumor antigen p53, Cys 51 Stop, EGK_08142, FLJ92943, HGNC11998, I79_002739, LFS1, Li-Fraumeni syndrome, mutant p53, mutant tumor protein 53, OTTMUSP00000006194, p44, p53, p53 cellular tumor antigen, p53 protein, p53 tumor suppressor, p53 tumor suppressor phosphoprotein, phosphoprotein p53, Tp53, tp53.L, transformation related protein 53, transformation-related protein 53, Trp248, Trp53, tumor protein 53, tumor protein p53, tumor protein p53 (Li-Fraumeni syndrome), tumor protein p53 L homeolog, tumor suppressor p53, tumor suppressor p53 phosphoprotein, tumor suppressor protein p53, tumor supressor p53, Tumour Protein p53, XELAEV_180196761mg, Xp53, Xrel3
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
22059, 24842, 7157
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress
- p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides
- p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest
- The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain
- There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization
- p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent
- Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors
- In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory
- p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy
- Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity
- Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
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Antigen: Acetyl-P53 (Lys370)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P02340, P04637, P10361
Gene Symbols: Tp53, Trp53
Immunogen: Synthetic peptide within Human p53 aa 343-392
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Western Blot, Western Blot
Clone: SR40-09
Conjugate: Unconjugated
Gene: Tp53
Gene Alias: Antigen NY-CO-13, bbl, BCC7, bfy, bhy, cellular tumor antigen p53, Cys 51 Stop, EGK_08142, FLJ92943, HGNC11998, I79_002739, LFS1, Li-Fraumeni syndrome, mutant p53, mutant tumor protein 53, OTTMUSP00000006194, p44, p53, p53 cellular tumor antigen, p53 protein, p53 tumor suppressor, p53 tumor suppressor phosphoprotein, phosphoprotein p53, Tp53, tp53.L, transformation related protein 53, transformation-related protein 53, Trp248, Trp53, tumor protein 53, tumor protein p53, tumor protein p53 (Li-Fraumeni syndrome), tumor protein p53 L homeolog, tumor suppressor p53, tumor suppressor p53 phosphoprotein, tumor suppressor protein p53, tumor supressor p53, Tumour Protein p53, XELAEV_180196761mg, Xp53, Xrel3
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 22059, 24842, 7157
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Acetyl-P53 (Lys370)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P02340, P04637, P10361
Gene Symbols:
Tp53, Trp53
Immunogen:
Synthetic peptide within Human p53 aa 343-392
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot, Western Blot
Clone:
SR40-09
Conjugate:
Unconjugated
Gene:
Tp53
Gene Alias:
Antigen NY-CO-13, bbl, BCC7, bfy, bhy, cellular tumor antigen p53, Cys 51 Stop, EGK_08142, FLJ92943, HGNC11998, I79_002739, LFS1, Li-Fraumeni syndrome, mutant p53, mutant tumor protein 53, OTTMUSP00000006194, p44, p53, p53 cellular tumor antigen, p53 protein, p53 tumor suppressor, p53 tumor suppressor phosphoprotein, phosphoprotein p53, Tp53, tp53.L, transformation related protein 53, transformation-related protein 53, Trp248, Trp53, tumor protein 53, tumor protein p53, tumor protein p53 (Li-Fraumeni syndrome), tumor protein p53 L homeolog, tumor suppressor p53, tumor suppressor p53 phosphoprotein, tumor suppressor protein p53, tumor supressor p53, Tumour Protein p53, XELAEV_180196761mg, Xp53, Xrel3
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
22059, 24842, 7157
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: beta-5 Tubulin
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P07437, P69897, P99024
Gene Symbols: TUBB, Tubb5
Immunogen: Synthetic peptide within Human beta Tubulin aa 308-357
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SR25-04
Conjugate: Unconjugated
Gene: TUBB
Gene Alias: AA408537, AI596182, B130022C14Rik, beta Ib tubulin, CDCBM6, CSCSC1, M(beta)5, M40, OK/SW-cl.56, tbb5, TUBB, TUBB1, TUBB5, tubulin beta, Tubulin beta chain, tubulin beta class I, tubulin beta-1 chain, tubulin beta-5 chain, tubulin, beta 5 class I, tubulin, beta class I, tubulin, beta polypeptide
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 203068, 22154, 29214
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
beta-5 Tubulin
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P07437, P69897, P99024
Gene Symbols:
TUBB, Tubb5
Immunogen:
Synthetic peptide within Human beta Tubulin aa 308-357
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SR25-04
Conjugate:
Unconjugated
Gene:
TUBB
Gene Alias:
AA408537, AI596182, B130022C14Rik, beta Ib tubulin, CDCBM6, CSCSC1, M(beta)5, M40, OK/SW-cl.56, tbb5, TUBB, TUBB1, TUBB5, tubulin beta, Tubulin beta chain, tubulin beta class I, tubulin beta-1 chain, tubulin beta-5 chain, tubulin, beta 5 class I, tubulin, beta class I, tubulin, beta polypeptide
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
203068, 22154, 29214
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: H4K5ac
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P62805, P62806
Gene Symbols: H4-16, H4C1, H4C11, H4C14, H4C2, H4C5, H4C9
Immunogen: Synthetic peptide within Human Histone H4 aa 1-50
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: ChIP Assay, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SR31-07
Conjugate: Unconjugated
Gene: H4C1
Gene Alias: acetyl Histone H4, Acetyl-H4 K5, Acetyl-H4 Lys5, Acetyl-Histone H4 K5, Acetyl-Histone H4 Lys5, B130044J01Rik, FO108, germinal histone H4, H1ft, H4, H4 histone family, member A, H4 histone family, member I, H4 histone family, member J, H4 histone family, member M, H4 histone family, member N, H4 histone, family 2, H4 K5ac, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/j, H4/K, H4/M, H4/n, H4/O, H4/p, H4-12, H4-16, H4-53, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C2, H4c3, H4C4, H4C5, H4c6, H4c8, H4C9, H4f16, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, H4ft, H4K5, H4Lys5ac, H4M, HIST1H4, Hist1h4a, HIST1H4B, Hist1h4c, Hist1h4d, HIST1H4E, HIST1H4F, Hist1h4h, HIST1H4I, Hist1h4j, HIST1H4K, HIST1H4L, Hist1h4m, HIST2H4, HIST2H4A, HIST2H4B, Hist4, Hist4h4, histone 1, H4a, histone 1, H4b, histone 1, H4e, histone 1, H4i, histone 2, H4, histone 2, H4a, Histone 4, Histone 4 family, member M, histone 4, H4, histone cluster 1, H4a, histone cluster 1, H4b, histone cluster 1, H4e, histone cluster 1, H4i, histone cluster 2, H4, histone cluster 2, H4a, Histone Cluster 4, histone cluster 4, H4, histone family member, histone H4, Histone H4 acetyl, Histone H4A, Histone H4K5, Histone H4K5ac, histone IV, family 2, LOC680097, OGP, Osteogenic growth peptide, RGD1565073, similar to germinal histone H4 gene, X04652
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 121504, 319158, 326619, 326620, 8294, 8359, 8363, 8366, 8367, 8370, 97122
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
H4K5ac
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P62805, P62806
Gene Symbols:
H4-16, H4C1, H4C11, H4C14, H4C2, H4C5, H4C9
Immunogen:
Synthetic peptide within Human Histone H4 aa 1-50
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
ChIP Assay, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SR31-07
Conjugate:
Unconjugated
Gene:
H4C1
Gene Alias:
acetyl Histone H4, Acetyl-H4 K5, Acetyl-H4 Lys5, Acetyl-Histone H4 K5, Acetyl-Histone H4 Lys5, B130044J01Rik, FO108, germinal histone H4, H1ft, H4, H4 histone family, member A, H4 histone family, member I, H4 histone family, member J, H4 histone family, member M, H4 histone family, member N, H4 histone, family 2, H4 K5ac, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/j, H4/K, H4/M, H4/n, H4/O, H4/p, H4-12, H4-16, H4-53, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C2, H4c3, H4C4, H4C5, H4c6, H4c8, H4C9, H4f16, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, H4ft, H4K5, H4Lys5ac, H4M, HIST1H4, Hist1h4a, HIST1H4B, Hist1h4c, Hist1h4d, HIST1H4E, HIST1H4F, Hist1h4h, HIST1H4I, Hist1h4j, HIST1H4K, HIST1H4L, Hist1h4m, HIST2H4, HIST2H4A, HIST2H4B, Hist4, Hist4h4, histone 1, H4a, histone 1, H4b, histone 1, H4e, histone 1, H4i, histone 2, H4, histone 2, H4a, Histone 4, Histone 4 family, member M, histone 4, H4, histone cluster 1, H4a, histone cluster 1, H4b, histone cluster 1, H4e, histone cluster 1, H4i, histone cluster 2, H4, histone cluster 2, H4a, Histone Cluster 4, histone cluster 4, H4, histone family member, histone H4, Histone H4 acetyl, Histone H4A, Histone H4K5, Histone H4K5ac, histone IV, family 2, LOC680097, OGP, Osteogenic growth peptide, RGD1565073, similar to germinal histone H4 gene, X04652
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
121504, 319158, 326619, 326620, 8294, 8359, 8363, 8366, 8367, 8370, 97122
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: MMP12
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P34960, P39900, Q63341
Gene Symbols: Mmp12
Immunogen: Synthetic peptide within Human MMP12 aa 421-470
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SR03-23
Conjugate: Unconjugated
Gene: Mmp12
Gene Alias: 3.4.24.65, AV378681, HME, Macrophage elastase, macrophage metalloelastase, macrophage-metalloelastase, matrix metallo protease, matrix metallopeptidase 12, matrix metallopeptidase 12 (macrophage elastase), matrix metalloproteinase 12, matrix metalloproteinase 12 (macrophage elastase), matrix metalloproteinase-12, ME, MGC138506, MME, Mmel, MMP, Mmp12, MMP-12, MMPs
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 117033, 17381, 4321
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
MMP12
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P34960, P39900, Q63341
Gene Symbols:
Mmp12
Immunogen:
Synthetic peptide within Human MMP12 aa 421-470
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SR03-23
Conjugate:
Unconjugated
Gene:
Mmp12
Gene Alias:
3.4.24.65, AV378681, HME, Macrophage elastase, macrophage metalloelastase, macrophage-metalloelastase, matrix metallo protease, matrix metallopeptidase 12, matrix metallopeptidase 12 (macrophage elastase), matrix metalloproteinase 12, matrix metalloproteinase 12 (macrophage elastase), matrix metalloproteinase-12, ME, MGC138506, MME, Mmel, MMP, Mmp12, MMP-12, MMPs
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
117033, 17381, 4321
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid