MERS Coronavirus Spike Protein S1 Monoclonal Antibody (3871), Invitrogen™

Description

• Does not cross react with the SARS Coronavirus
• The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity
• The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together
• The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process
• Most notable is severe acute respiratory syndrome (SARS)
• The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion
• It is also a major immunogen and a target for entry inhibitors
• The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes
• The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.