PIMA535263
Presenilin 1 Recombinant Rabbit Monoclonal Antibody (ARC0440), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA535263-Each-of-1 | In Stock | ₹ 45,646.26 |
PIMA535263 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,646.26
GST (18%): ₹ 8,216.327
Total Price: ₹ 53,862.587
Antigen
Presenilin 1
Classification
Monoclonal
Concentration
1.05 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P49768, P49769, P97887
Gene Symbols
PSEN1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Presenilin 1 (P49768)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
ARC0440
Conjugate
Unconjugated
Gene
PSEN1
Gene Alias
AD3; Ad3h; Alzheimer Disease 3; FAD; Minilin; presenilin 1; presenilin 1 (Alzheimer disease 3); presenilin1; presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS1; PS-1; PS1-CTF12; PSEN1; Psnl1; S182; S182 protein; Senilin 1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19164, 29192, 5663
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Description
- Immunogen sequence: MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL SNGRPQGNSR QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease
- In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer
- This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease
- Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site)
- It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease
- Multiple isoforms of presenilin1 are known to exist.
Compare Similar Items
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Antigen: Presenilin 1
Classification: Monoclonal
Concentration: 1.05 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P49768, P49769, P97887
Gene Symbols: PSEN1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Presenilin 1 (P49768)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC0440
Conjugate: Unconjugated
Gene: PSEN1
Gene Alias: AD3; Ad3h; Alzheimer Disease 3; FAD; Minilin; presenilin 1; presenilin 1 (Alzheimer disease 3); presenilin1; presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS1; PS-1; PS1-CTF12; PSEN1; Psnl1; S182; S182 protein; Senilin 1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 19164, 29192, 5663
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Presenilin 1
Classification:
Monoclonal
Concentration:
1.05 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P49768, P49769, P97887
Gene Symbols:
PSEN1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Presenilin 1 (P49768)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC0440
Conjugate:
Unconjugated
Gene:
PSEN1
Gene Alias:
AD3; Ad3h; Alzheimer Disease 3; FAD; Minilin; presenilin 1; presenilin 1 (Alzheimer disease 3); presenilin1; presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS1; PS-1; PS1-CTF12; PSEN1; Psnl1; S182; S182 protein; Senilin 1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
19164, 29192, 5663
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: RhoA
Classification: Monoclonal
Concentration: 1.17 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P61586
Gene Symbols: RHOA
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RhoA (P61586)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC0372
Conjugate: Unconjugated
Gene: RHOA
Gene Alias: Aplysia ras-related homolog 12; Aplysia RAS-related homolog 6; aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; ARH12; ARH6; ARH9; ARHA; Arha1; Arha2; ARHB; ARHC; h12; h6; H9; MGC72339; MST081; MSTP081; oncogene RHO H12; oncogene RHO H6; oncogene RHO H9; plysia ras-related homolog A2; Ras family member A; ras homolog A1; ras homolog A2; ras homolog family member A; ras homolog family member B; ras homolog family member C; ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; ras homolog gene family, member B; ras homolog gene family, member C; RAS-related homolog 9; Rho; Rho cDNA clone 12; Rho cDNA clone 6; rho cDNA clone 9; Rho family GTPase; RHO12; Rhoa; RHOB; RHOC; rhoC GTPase; RHOH12; RHOH6; RHOH9; rho-related GTP-binding protein RhoB; Rho-related GTP-binding protein RhoC; small GTP binding protein RhoA; small GTP binding protein RhoC; transforming protein RhoA
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 387
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
RhoA
Classification:
Monoclonal
Concentration:
1.17 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P61586
Gene Symbols:
RHOA
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RhoA (P61586)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC0372
Conjugate:
Unconjugated
Gene:
RHOA
Gene Alias:
Aplysia ras-related homolog 12; Aplysia RAS-related homolog 6; aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; ARH12; ARH6; ARH9; ARHA; Arha1; Arha2; ARHB; ARHC; h12; h6; H9; MGC72339; MST081; MSTP081; oncogene RHO H12; oncogene RHO H6; oncogene RHO H9; plysia ras-related homolog A2; Ras family member A; ras homolog A1; ras homolog A2; ras homolog family member A; ras homolog family member B; ras homolog family member C; ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; ras homolog gene family, member B; ras homolog gene family, member C; RAS-related homolog 9; Rho; Rho cDNA clone 12; Rho cDNA clone 6; rho cDNA clone 9; Rho family GTPase; RHO12; Rhoa; RHOB; RHOC; rhoC GTPase; RHOH12; RHOH6; RHOH9; rho-related GTP-binding protein RhoB; Rho-related GTP-binding protein RhoC; small GTP binding protein RhoA; small GTP binding protein RhoC; transforming protein RhoA
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
387
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: SHP2
Classification: Monoclonal
Concentration: 0.1 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P35235, P41499, Q06124
Gene Symbols: PTPN11
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SHP2 (Q06124)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Clone: 3Q4U2
Conjugate: Unconjugated
Gene: PTPN11
Gene Alias: 2700084A17Rik; AW536184; bptp3; CFC; cSH-PTP2; encodes catalytic domain; HCP; HGNC:9644; JMML; METCDS; MGC14433; Noonan syndrome 1; ns1; null; OTTHUMP00000166108; phosphotyrosyl-protein phosphatase; protein tyrosine phosphatase non-receptor type 11; protein tyrosine phosphatase SH-PTP2; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1); protein tyrosine phosphatase, non-receptor type 11 S homeolog; protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; protein-tyrosine phosphatase SYP; PTP1C; PTP1D; PTP-1D; ptp-2; PTP2C; PTP-2C; Ptpn11; ptpn11.S; ptpn11-a; ptpn11-b; SAP-2; SH2 domain-containing protein tyrosine phosphatase-2; Shp2; shp-2; SHPTP2; SH-PTP2; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SH-PTP3; Syp; Tyrosine-protein phosphatase non-receptor type 11; XELAEV_18010676mg
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 19247, 25622, 5781
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
SHP2
Classification:
Monoclonal
Concentration:
0.1 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P35235, P41499, Q06124
Gene Symbols:
PTPN11
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SHP2 (Q06124)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Clone:
3Q4U2
Conjugate:
Unconjugated
Gene:
PTPN11
Gene Alias:
2700084A17Rik; AW536184; bptp3; CFC; cSH-PTP2; encodes catalytic domain; HCP; HGNC:9644; JMML; METCDS; MGC14433; Noonan syndrome 1; ns1; null; OTTHUMP00000166108; phosphotyrosyl-protein phosphatase; protein tyrosine phosphatase non-receptor type 11; protein tyrosine phosphatase SH-PTP2; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1); protein tyrosine phosphatase, non-receptor type 11 S homeolog; protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; protein-tyrosine phosphatase SYP; PTP1C; PTP1D; PTP-1D; ptp-2; PTP2C; PTP-2C; Ptpn11; ptpn11.S; ptpn11-a; ptpn11-b; SAP-2; SH2 domain-containing protein tyrosine phosphatase-2; Shp2; shp-2; SHPTP2; SH-PTP2; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SH-PTP3; Syp; Tyrosine-protein phosphatase non-receptor type 11; XELAEV_18010676mg
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
19247, 25622, 5781
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: SMAD5
Classification: Monoclonal
Concentration: 0.75 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P97454, Q99717
Gene Symbols: SMAD5
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Smad5 (Q99717)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Immunoprecipitation, Western Blot
Clone: ARC0448
Conjugate: Unconjugated
Gene: SMAD5
Gene Alias: 1110051M15Rik; AI451355; DKFZp781C1895; DKFZp781O1323; dwarfin-C; DWFC; Dwf-C; hSmad5; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; Madh5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; mothers against DPP homolog 5; mSmad5; MusMLP; OTTHUMP00000223331; SMA- and MAD-related protein 5; SMAD; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; SMAD5
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17129, 4090
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
SMAD5
Classification:
Monoclonal
Concentration:
0.75 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P97454, Q99717
Gene Symbols:
SMAD5
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Smad5 (Q99717)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunoprecipitation, Western Blot
Clone:
ARC0448
Conjugate:
Unconjugated
Gene:
SMAD5
Gene Alias:
1110051M15Rik; AI451355; DKFZp781C1895; DKFZp781O1323; dwarfin-C; DWFC; Dwf-C; hSmad5; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; Madh5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; mothers against DPP homolog 5; mSmad5; MusMLP; OTTHUMP00000223331; SMA- and MAD-related protein 5; SMAD; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; SMAD5
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17129, 4090
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid