PIMA535804
SIRP alpha Recombinant Rabbit Monoclonal Antibody (ARC1626), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA535804-Each-of-1 | In Stock | ₹ 45,646.26 |
PIMA535804 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,646.26
GST (18%): ₹ 8,216.327
Total Price: ₹ 53,862.587
Antigen
SIRP alpha
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P78324, P97710, P97797
Gene Symbols
SIRPA
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 395-495 of human CD172a/SIRP alpha (P78324)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
ARC1626
Conjugate
Unconjugated
Gene
SIRPA
Gene Alias
AI835480; Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172A; Inhibitory receptor SHPS-1; macrophage fusion receptor; Macrophage membrane protein MFP150; MFR; mSIRP-alpha1; Myd1; MYD-1; myD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; SIRP; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
140885, 19261, 25528
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Description
- Immunogen sequence: RIRQKKAQGS TSSTRLHEPE KNAREITQDT NDITYADLNL PKGKKPAPQA AEPNNHTEYA SIQTSPQPAS EDTLTYADLD MVHLNRTPKQ PAPKPEPSFS E SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and hematopoietic stem cells
- SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways
- The ligand binding of SIRP alpha to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, which mediates the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2
- Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs
- SIRP alpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion, and plays a general role in different physiological and pathological processes
- Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of cancerous cell growth.
Compare Similar Items
Show Difference
Antigen: SIRP alpha
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P78324, P97710, P97797
Gene Symbols: SIRPA
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 395-495 of human CD172a/SIRP alpha (P78324)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Clone: ARC1626
Conjugate: Unconjugated
Gene: SIRPA
Gene Alias: AI835480; Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172A; Inhibitory receptor SHPS-1; macrophage fusion receptor; Macrophage membrane protein MFP150; MFR; mSIRP-alpha1; Myd1; MYD-1; myD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; SIRP; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 140885, 19261, 25528
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
SIRP alpha
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P78324, P97710, P97797
Gene Symbols:
SIRPA
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 395-495 of human CD172a/SIRP alpha (P78324)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Clone:
ARC1626
Conjugate:
Unconjugated
Gene:
SIRPA
Gene Alias:
AI835480; Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172A; Inhibitory receptor SHPS-1; macrophage fusion receptor; Macrophage membrane protein MFP150; MFR; mSIRP-alpha1; Myd1; MYD-1; myD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; SIRP; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
140885, 19261, 25528
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: HIPK2
Classification: Monoclonal
Concentration: 0.3 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q9H2X6
Gene Symbols: HIPK2
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HIPK2 (Q9H2X6)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Clone: ARC1631
Conjugate: Unconjugated
Gene: HIPK2
Gene Alias: 1110014O20Rik; B230339E18Rik; cb1009; hHIPk2; HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; Nbak1; Nuclear body-associated kinase 1; PRO0593; si:dkey-16j24.2; si:dkey-239k7.1; Sialophorin tail-associated nuclear serine/threonine-protein kinase; Stank; wu:fk56d12
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 28996
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
HIPK2
Classification:
Monoclonal
Concentration:
0.3 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q9H2X6
Gene Symbols:
HIPK2
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HIPK2 (Q9H2X6)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Clone:
ARC1631
Conjugate:
Unconjugated
Gene:
HIPK2
Gene Alias:
1110014O20Rik; B230339E18Rik; cb1009; hHIPk2; HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; Nbak1; Nuclear body-associated kinase 1; PRO0593; si:dkey-16j24.2; si:dkey-239k7.1; Sialophorin tail-associated nuclear serine/threonine-protein kinase; Stank; wu:fk56d12
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
28996
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: HOXA13
Classification: Monoclonal
Concentration: 2.67 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P31271, Q62424
Gene Symbols: Hoxa13
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HOXA13 (P31271)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC1636
Conjugate: Unconjugated
Gene: Hoxa13
Gene Alias: Hd; homeo box 1J; homeo box A13; homeobox A13; homeobox protein Hox-1.10; Homeobox protein Hox-1J; homeobox protein HOXA13; homeobox protein Hox-A13; HOX1; Hox-1.10; HOX1J; HOXA13; hypodactyly; RGD1562483; transcription factor HOXA13
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 15398, 3209, 500129
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
HOXA13
Classification:
Monoclonal
Concentration:
2.67 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P31271, Q62424
Gene Symbols:
Hoxa13
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HOXA13 (P31271)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC1636
Conjugate:
Unconjugated
Gene:
Hoxa13
Gene Alias:
Hd; homeo box 1J; homeo box A13; homeobox A13; homeobox protein Hox-1.10; Homeobox protein Hox-1J; homeobox protein HOXA13; homeobox protein Hox-A13; HOX1; Hox-1.10; HOX1J; HOXA13; hypodactyly; RGD1562483; transcription factor HOXA13
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
15398, 3209, 500129
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Fascin
Classification: Monoclonal
Concentration: 0.28 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P85845, Q16658, Q61553
Gene Symbols: FSCN1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 249-362 of human Fascin/FSCN1 (Q16658)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: ARC1638
Conjugate: Unconjugated
Gene: FSCN1
Gene Alias: 55 kDa actin-bundling protein; 55kDa actin-bundling protein; AI663989; Fan1; fascin; fascin 1; fascin actin-bundling protein 1; Fascin homolog 1; fascin homolog 1, actin bundling protein; fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus); fascin homolog 1, actin-bundling protein; Fascin1; fascin-1; Fscn1; fscn1 {ECO:0000250; HSN; p55; Singed; Singed (Drosophila) like (sea urchin fascin homolog like); singed-like (fascin homolog, sea urchin); singed-like protein; SNL; UniProtKB:Q16658}
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 14086, 6624, 683788
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Fascin
Classification:
Monoclonal
Concentration:
0.28 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P85845, Q16658, Q61553
Gene Symbols:
FSCN1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 249-362 of human Fascin/FSCN1 (Q16658)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
ARC1638
Conjugate:
Unconjugated
Gene:
FSCN1
Gene Alias:
55 kDa actin-bundling protein; 55kDa actin-bundling protein; AI663989; Fan1; fascin; fascin 1; fascin actin-bundling protein 1; Fascin homolog 1; fascin homolog 1, actin bundling protein; fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus); fascin homolog 1, actin-bundling protein; Fascin1; fascin-1; Fscn1; fscn1 {ECO:0000250; HSN; p55; Singed; Singed (Drosophila) like (sea urchin fascin homolog like); singed-like (fascin homolog, sea urchin); singed-like protein; SNL; UniProtKB:Q16658}
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14086, 6624, 683788
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid