PIMA535846
Phospho-p53 (Ser376) Recombinant Rabbit Monoclonal Antibody (ARC1531), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA535846-Each-of-1 | In Stock | ₹ 48,640.86 |
PIMA535846 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,640.86
GST (18%): ₹ 8,755.355
Total Price: ₹ 57,396.215
Antigen
Phospho-p53 (Ser376)
Classification
Monoclonal
Concentration
1.4 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P04637, P10361
Gene Symbols
Tp53
Immunogen
A synthetic phosphorylated peptide around S376 of human p53 (P04637)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
ARC1531
Conjugate
Unconjugated
Gene
Tp53
Gene Alias
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
24842, 7157
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Description
- Immunogen sequence: GQSTS The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress
- p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides
- p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest
- The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain
- There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization
- p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent
- Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors
- In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory
- p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy
- Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity
- Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
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Antigen: Phospho-p53 (Ser376)
Classification: Monoclonal
Concentration: 1.4 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P04637, P10361
Gene Symbols: Tp53
Immunogen: A synthetic phosphorylated peptide around S376 of human p53 (P04637)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC1531
Conjugate: Unconjugated
Gene: Tp53
Gene Alias: Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 24842, 7157
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-p53 (Ser376)
Classification:
Monoclonal
Concentration:
1.4 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P04637, P10361
Gene Symbols:
Tp53
Immunogen:
A synthetic phosphorylated peptide around S376 of human p53 (P04637)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC1531
Conjugate:
Unconjugated
Gene:
Tp53
Gene Alias:
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
24842, 7157
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Phospho-c-Myc (Thr58)
Classification: Monoclonal
Concentration: 0.65 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P01106
Gene Symbols: MYC
Immunogen: A synthetic phosphorylated peptide around T58 of human c-Myc (P01106)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC1534
Conjugate: Unconjugated
Gene: MYC
Gene Alias: AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4609
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-c-Myc (Thr58)
Classification:
Monoclonal
Concentration:
0.65 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P01106
Gene Symbols:
MYC
Immunogen:
A synthetic phosphorylated peptide around T58 of human c-Myc (P01106)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC1534
Conjugate:
Unconjugated
Gene:
MYC
Gene Alias:
AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4609
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Phospho-EGFR (Tyr1068)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P00533
Gene Symbols: EGFR
Immunogen: A phospho specific peptide corresponding to residues surrounding Y1068 of human EGFR (P00533)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC1538
Conjugate: Unconjugated
Gene: EGFR
Gene Alias: 2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1956
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-EGFR (Tyr1068)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P00533
Gene Symbols:
EGFR
Immunogen:
A phospho specific peptide corresponding to residues surrounding Y1068 of human EGFR (P00533)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC1538
Conjugate:
Unconjugated
Gene:
EGFR
Gene Alias:
2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1956
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Phospho-IRF3 (Ser386)
Classification: Monoclonal
Concentration: 0.86 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q14653
Gene Symbols: IRF3
Immunogen: A synthetic phosphorylated peptide around S386 of human IRF3 (Q14653)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC1539
Conjugate: Unconjugated
Gene: IRF3
Gene Alias: C920001K05Rik; IIAE7; Interferon regulatory factor 3; IRF3; IRF-3; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3661
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-IRF3 (Ser386)
Classification:
Monoclonal
Concentration:
0.86 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q14653
Gene Symbols:
IRF3
Immunogen:
A synthetic phosphorylated peptide around S386 of human IRF3 (Q14653)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC1539
Conjugate:
Unconjugated
Gene:
IRF3
Gene Alias:
C920001K05Rik; IIAE7; Interferon regulatory factor 3; IRF3; IRF-3; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3661
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid