PIMA535888
Phospho-CDK1/CDK2/CDK3 (Thr14) Recombinant Rabbit Monoclonal Antibody (ARC1545), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA535888-Each-of-1 | In Stock | ₹ 48,640.86 |
PIMA535888 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,640.86
GST (18%): ₹ 8,755.355
Total Price: ₹ 57,396.215
Antigen
Phospho-CDK1/CDK2/CDK3 (Thr14)
Classification
Monoclonal
Concentration
0.4 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P06493, P11440, P24941, P39951, P97377, Q00526, Q63699
Gene Symbols
CDK1, CDK2, CDK3
Immunogen
A synthetic phosphorylated peptide around T14 of human CDK1/2/3CDK1 (P06493)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
ARC1545
Conjugate
Unconjugated
Gene
CDK2
Gene Alias
2310050O10Rik; A630093N05Rik; CDC2; CDC28A; Cdc2a; cdc2-related protein kinase; CDK1; CDK2; CDK3; Cdk3-ps; CDKN1; CDKN2; CDKN3; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; cell division protein kinase 1; Cell division protein kinase 2; cell division protein kinase 3; cyclin dependent kinase 1; cyclin dependent kinase 2; cyclin dependent kinase 2-alpha; cyclin dependent kinase 3; cyclin-dependent kinase 1; Cyclin-dependent kinase 2; cyclin-dependent kinase 3; cyclin-dependent kinase 3, pseudogene; p33 protein kinase; p33(CDK2); p34 protein kinase; p34<CDC2>; P34CDC2
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1017, 1018, 12534, 12566, 362817, 54237, 69681, 983
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Description
- Immunogen sequence: EGTYG Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins
- Required in higher cells for entry into S-phase and mitosis
- Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SIRT2 and RUNX2
- CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs
- Essential for early stages of embryonic development
- During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation
- Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1- mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis
- Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair
- Reactivated after successful DNA repair through WIP1- dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression
- In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons
- The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis
- NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the 2 centrosome, an important step for spindle formation
- In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis
- The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis
- In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis
- This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes
- EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing
- CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration
- CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230).
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Antigen: Phospho-CDK1/CDK2/CDK3 (Thr14)
Classification: Monoclonal
Concentration: 0.4 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P06493, P11440, P24941, P39951, P97377, Q00526, Q63699
Gene Symbols: CDK1, CDK2, CDK3
Immunogen: A synthetic phosphorylated peptide around T14 of human CDK1/2/3CDK1 (P06493)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC1545
Conjugate: Unconjugated
Gene: CDK2
Gene Alias: 2310050O10Rik; A630093N05Rik; CDC2; CDC28A; Cdc2a; cdc2-related protein kinase; CDK1; CDK2; CDK3; Cdk3-ps; CDKN1; CDKN2; CDKN3; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; cell division protein kinase 1; Cell division protein kinase 2; cell division protein kinase 3; cyclin dependent kinase 1; cyclin dependent kinase 2; cyclin dependent kinase 2-alpha; cyclin dependent kinase 3; cyclin-dependent kinase 1; Cyclin-dependent kinase 2; cyclin-dependent kinase 3; cyclin-dependent kinase 3, pseudogene; p33 protein kinase; p33(CDK2); p34 protein kinase; p34<CDC2>; P34CDC2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1017, 1018, 12534, 12566, 362817, 54237, 69681, 983
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-CDK1/CDK2/CDK3 (Thr14)
Classification:
Monoclonal
Concentration:
0.4 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P06493, P11440, P24941, P39951, P97377, Q00526, Q63699
Gene Symbols:
CDK1, CDK2, CDK3
Immunogen:
A synthetic phosphorylated peptide around T14 of human CDK1/2/3CDK1 (P06493)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC1545
Conjugate:
Unconjugated
Gene:
CDK2
Gene Alias:
2310050O10Rik; A630093N05Rik; CDC2; CDC28A; Cdc2a; cdc2-related protein kinase; CDK1; CDK2; CDK3; Cdk3-ps; CDKN1; CDKN2; CDKN3; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; cell division protein kinase 1; Cell division protein kinase 2; cell division protein kinase 3; cyclin dependent kinase 1; cyclin dependent kinase 2; cyclin dependent kinase 2-alpha; cyclin dependent kinase 3; cyclin-dependent kinase 1; Cyclin-dependent kinase 2; cyclin-dependent kinase 3; cyclin-dependent kinase 3, pseudogene; p33 protein kinase; p33(CDK2); p34 protein kinase; p34<CDC2>; P34CDC2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1017, 1018, 12534, 12566, 362817, 54237, 69681, 983
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Phospho-Cdc37 (Ser13)
Classification: Monoclonal
Concentration: 0.09 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q16543, Q61081, Q63692
Gene Symbols: CDC37
Immunogen: A synthetic phosphorylated peptide around S13 of human CDC37 (Q16543)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC1602
Conjugate: Unconjugated
Gene: CDC37
Gene Alias: CDC 37; CDC37; CDC37 (cell division cycle 37 S. cerevisiae homolog); CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog; Cdc37 homolog; CDC37 protein; CDC37A; Cdc37p; Cell division control protein 37; cell division cycle 37; cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; p50; P50CDC37; SMO1; YD9489.03; YDR168W
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11140, 114562, 12539
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-Cdc37 (Ser13)
Classification:
Monoclonal
Concentration:
0.09 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q16543, Q61081, Q63692
Gene Symbols:
CDC37
Immunogen:
A synthetic phosphorylated peptide around S13 of human CDC37 (Q16543)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC1602
Conjugate:
Unconjugated
Gene:
CDC37
Gene Alias:
CDC 37; CDC37; CDC37 (cell division cycle 37 S. cerevisiae homolog); CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog; Cdc37 homolog; CDC37 protein; CDC37A; Cdc37p; Cell division control protein 37; cell division cycle 37; cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; p50; P50CDC37; SMO1; YD9489.03; YDR168W
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11140, 114562, 12539
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Phospho-SMC1 (Ser957)
Classification: Monoclonal
Concentration: 0.61 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q14683, Q8NDV3, Q920F6, Q9CU62, Q9Z1M9
Gene Symbols: SMC1A, SMC1B
Immunogen: A synthetic phosphorylated peptide around S957 of human SMC1 (Q14683)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: ARC1606
Conjugate: Unconjugated
Gene: SMC1A
Gene Alias: 14S cohesin SMC1 subunit; 5830426I24Rik; CDLS2; chromosome segregation protein SmcB; DKFZp686L19178; DXhXs423e; DXS423E; KIAA0178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; mKIAA0178; RP6-29D12.1; Sb1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; segregation of mitotic chromosomes-like 1; SM1A; SMC; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein; SMC protein 1A; SMC protein 1B; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 protein; SMC1 protein cohesin subunit; SMC1 structural maintenance of chromosomes 1-like 1; SMC1 structural maintenance of chromosomes 1-like 2; Smc1a; SMC-1A; smc1a.L; smc1aa; Smc1alpha; SMC-1-alpha; SMC1alpha protein; Smc1b; SMC-1B; SMC1BETA; SMC-1-beta; SMC1L1; Smc1l2; Smcb; SMC-like 1; SMC-protein; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1; structural maintenance of chromosomes 1 like 1; structural maintenance of c
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 140557, 24061, 27127, 300121, 63996, 8243
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-SMC1 (Ser957)
Classification:
Monoclonal
Concentration:
0.61 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q14683, Q8NDV3, Q920F6, Q9CU62, Q9Z1M9
Gene Symbols:
SMC1A, SMC1B
Immunogen:
A synthetic phosphorylated peptide around S957 of human SMC1 (Q14683)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
ARC1606
Conjugate:
Unconjugated
Gene:
SMC1A
Gene Alias:
14S cohesin SMC1 subunit; 5830426I24Rik; CDLS2; chromosome segregation protein SmcB; DKFZp686L19178; DXhXs423e; DXS423E; KIAA0178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; mKIAA0178; RP6-29D12.1; Sb1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; segregation of mitotic chromosomes-like 1; SM1A; SMC; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein; SMC protein 1A; SMC protein 1B; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 protein; SMC1 protein cohesin subunit; SMC1 structural maintenance of chromosomes 1-like 1; SMC1 structural maintenance of chromosomes 1-like 2; Smc1a; SMC-1A; smc1a.L; smc1aa; Smc1alpha; SMC-1-alpha; SMC1alpha protein; Smc1b; SMC-1B; SMC1BETA; SMC-1-beta; SMC1L1; Smc1l2; Smcb; SMC-like 1; SMC-protein; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1; structural maintenance of chromosomes 1 like 1; structural maintenance of c
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
140557, 24061, 27127, 300121, 63996, 8243
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Phospho-PKC zeta (Thr560)
Classification: Monoclonal
Concentration: 1.05 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P09217, Q05513
Gene Symbols: PRKCZ
Immunogen: A synthetic phosphorylated peptide around T560 of human PKC zeta (Q05513)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC1617
Conjugate: Unconjugated
Gene: PRKCZ
Gene Alias: 14 - 3 - 3 - zeta isoform; 14-3-3-zetaisoform; AI098070; aPKCzeta; atypical protein kinase C; C80388; kinase nPKC-zeta; KPCZ; nPKC-zeta; nPKC-zeta PRKCZ; PKC2; Pkcz; PKC-ZETA; Prkcz; protein kinase C zeta; protein kinase C zeta subspecies; protein kinase C zeta type; protein kinase C, zeta; r14-3-3; R74924; zetaPKC
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 25522, 5590
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-PKC zeta (Thr560)
Classification:
Monoclonal
Concentration:
1.05 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P09217, Q05513
Gene Symbols:
PRKCZ
Immunogen:
A synthetic phosphorylated peptide around T560 of human PKC zeta (Q05513)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC1617
Conjugate:
Unconjugated
Gene:
PRKCZ
Gene Alias:
14 - 3 - 3 - zeta isoform; 14-3-3-zetaisoform; AI098070; aPKCzeta; atypical protein kinase C; C80388; kinase nPKC-zeta; KPCZ; nPKC-zeta; nPKC-zeta PRKCZ; PKC2; Pkcz; PKC-ZETA; Prkcz; protein kinase C zeta; protein kinase C zeta subspecies; protein kinase C zeta type; protein kinase C, zeta; r14-3-3; R74924; zetaPKC
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
25522, 5590
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid