PIMA537835
ROCK1 Recombinant Rabbit Monoclonal Antibody (ARC2371), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA537835-Each-of-1 | In Stock | ₹ 46,501.86 |
PIMA537835 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,501.86
GST (18%): ₹ 8,370.335
Total Price: ₹ 54,872.195
Antigen
ROCK1
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P70335, Q13464, Q63644
Gene Symbols
Rock1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1100-1200 of human ROCK1 (Q13464)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
ARC2371
Conjugate
Unconjugated
Gene
Rock1
Gene Alias
1110055K06Rik; Ac2-154; Liver regeneration-related protein LRRG199; MGC131603; MGC43611; p150 RhoA-binding kinase ROK beta; p160 ROCK-1; p160ROCK; p160-ROCK; PRO0435; Renal carcinoma antigen NY-REN-35; Rho associated coiled-coil containing protein kinase 1; Rho kinase; Rho-associated coiled-coil containing protein kinase 1; Rho-associated coiled-coil forming kinase 1; Rho-associated kinase beta; rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK1; ROCK-I
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19877, 6093, 81762
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Positive Samples: HT-29, HepG2, Jurkat, C6, Mouse lung, Rat liver Immunogen sequence: STSVASFPSA DETDGNLPES RIEGWLSVPN RGNIKRYGWK KQYVVVSSKK ILFYNDEQDK EQSNPSMVLD IDKLFHVRPV TQGDVYRAET EEIPKIFQIL Y ROCK1 is a serine/threonine kinase that regulates cell differentiation and migration
- The Rho/ROCK pathway is involved in the progression of various human cancers
- ROCK1 has been found to be a new Caspase-3 substrate
- ROCK, one of the effectors of the small GTPase Rho, has recently been shown to contribute significantly to myosin light chain (MLC) activation through two pathways: direct phosphorylation of MLC and phosphorylation of MLC phosphatase, leading to its inhibition
- The increase in cellular contractility that is necessary for apoptotic membrane blebbing implies sustained augmentation of MLC phosphorylation
- ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain that is located within a pleckstrin-homology region
- They are joined by a variable region that contains the Rho-binding domain
- During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity
- The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane blebbing, one of the first events in the execution phase of apoptosis.
Compare Similar Items
Show Difference
Antigen: ROCK1
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P70335, Q13464, Q63644
Gene Symbols: Rock1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1100-1200 of human ROCK1 (Q13464)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC2371
Conjugate: Unconjugated
Gene: Rock1
Gene Alias: 1110055K06Rik; Ac2-154; Liver regeneration-related protein LRRG199; MGC131603; MGC43611; p150 RhoA-binding kinase ROK beta; p160 ROCK-1; p160ROCK; p160-ROCK; PRO0435; Renal carcinoma antigen NY-REN-35; Rho associated coiled-coil containing protein kinase 1; Rho kinase; Rho-associated coiled-coil containing protein kinase 1; Rho-associated coiled-coil forming kinase 1; Rho-associated kinase beta; rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK1; ROCK-I
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 19877, 6093, 81762
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
ROCK1
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P70335, Q13464, Q63644
Gene Symbols:
Rock1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1100-1200 of human ROCK1 (Q13464)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC2371
Conjugate:
Unconjugated
Gene:
Rock1
Gene Alias:
1110055K06Rik; Ac2-154; Liver regeneration-related protein LRRG199; MGC131603; MGC43611; p150 RhoA-binding kinase ROK beta; p160 ROCK-1; p160ROCK; p160-ROCK; PRO0435; Renal carcinoma antigen NY-REN-35; Rho associated coiled-coil containing protein kinase 1; Rho kinase; Rho-associated coiled-coil containing protein kinase 1; Rho-associated coiled-coil forming kinase 1; Rho-associated kinase beta; rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK1; ROCK-I
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
19877, 6093, 81762
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: GCLM
Classification: Recombinant Monoclonal
Concentration: 1.25 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P48507
Gene Symbols: Gclm
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 175-274 of human GCLM (P48507)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ARC0597
Conjugate: Unconjugated
Gene: Gclm
Gene Alias: AI649393; gamma glutamylcysteine synthetase; gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Gclm; Gcmc; GCS light chain; Glclr; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate cysteine ligase, modifier subunit; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD); glutamate-cysteine ligase modifier subunit; glutamate--cysteine ligase modifier subunit; glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase regulatory protein; Glutamate--cysteine ligase regulatory subunit; glutamate-cysteine ligase, modifier subunit; GSC light chain; null
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 2730
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
GCLM
Classification:
Recombinant Monoclonal
Concentration:
1.25 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P48507
Gene Symbols:
Gclm
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 175-274 of human GCLM (P48507)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ARC0597
Conjugate:
Unconjugated
Gene:
Gclm
Gene Alias:
AI649393; gamma glutamylcysteine synthetase; gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Gclm; Gcmc; GCS light chain; Glclr; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate cysteine ligase, modifier subunit; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD); glutamate-cysteine ligase modifier subunit; glutamate--cysteine ligase modifier subunit; glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase regulatory protein; Glutamate--cysteine ligase regulatory subunit; glutamate-cysteine ligase, modifier subunit; GSC light chain; null
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
2730
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: CD27
Classification: Recombinant Monoclonal
Concentration: 0.4 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P26842
Gene Symbols: CD27
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD27 (P26842)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: ARC0625
Conjugate: Unconjugated
Gene: CD27
Gene Alias: CD antigen 27; CD27; CD27 antigen; CD27 molecule; CD27L receptor; LPFS2; S152; S152. LPFS2; sCD27; soluble CD27; T cell activation antigen S152; T14; T-cell activation antigen CD27; TNFRSF7; TNFSF7; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 500318, 939
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
CD27
Classification:
Recombinant Monoclonal
Concentration:
0.4 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P26842
Gene Symbols:
CD27
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD27 (P26842)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
ARC0625
Conjugate:
Unconjugated
Gene:
CD27
Gene Alias:
CD antigen 27; CD27; CD27 antigen; CD27 molecule; CD27L receptor; LPFS2; S152; S152. LPFS2; sCD27; soluble CD27; T cell activation antigen S152; T14; T-cell activation antigen CD27; TNFRSF7; TNFSF7; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
500318, 939
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: E2F6
Classification: Recombinant Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: O75461
Gene Symbols: E2F6
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 110-281 of human E2F6 (NP_937987.2)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: ChIP Assay, CUT&RUN, Immunoprecipitation, Western Blot
Clone: ARC0628
Conjugate: Unconjugated
Gene: E2F6
Gene Alias: AI462434; E2F transcription factor 6; E2f6; E2F-6; E2F6b; E2F-binding site-modulating activity protein; EMA; MGC111545; Transcription factor E2F6; transcriptional repressor E2F6
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1876
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
E2F6
Classification:
Recombinant Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
O75461
Gene Symbols:
E2F6
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 110-281 of human E2F6 (NP_937987.2)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
ChIP Assay, CUT&RUN, Immunoprecipitation, Western Blot
Clone:
ARC0628
Conjugate:
Unconjugated
Gene:
E2F6
Gene Alias:
AI462434; E2F transcription factor 6; E2f6; E2F-6; E2F6b; E2F-binding site-modulating activity protein; EMA; MGC111545; Transcription factor E2F6; transcriptional repressor E2F6
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1876
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid