Nofetumomab Recombinant Mouse Monoclonal Antibody, Invitrogen™

Description

• Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles
• Store at 2 to 8 °C for one week
• Store at -20 to -80 °C for twelve months from the date of receipt
• Technetium Tc-99m nofetumomab merpentan (Tc-99m nm) consists of a Fab fragment of an IgG2b of the pancarcinoma murine antibody NR-LU-10
• 1The NR-LU-10 antibody is directed against a 40 kDa glycoprotein antigen expressed in a variety of cancers and some normal tissues
• LabelTc-99m nm was developed by Boehringer Ingelheim Pharma KG and FDA approved on September 14, 1992
• It was after discontinued on August 13, 2013, but in the 2018 FDA submission list, it can be found as a substance type II (pharmaceutical substance) with an active status
• The mechanism of action in Tc-99m nm is ruled by the presence of nofetumomab, which can recognize the pancarcinoma antigen EpCAM and/or CD20/MS4A1, 2and merpentan, that acts as a linker for the binding of technetium.