Tacatuzumab Recombinant Human Monoclonal Antibody, Invitrogen™

Description

• Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles
• Store at 2 to 8 °C for one week
• Store at -20 to -80 °C for twelve months from the date of receipt
• Tacatuzumab is a biosimilar that targets AFP
• AFP (alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract and the liver during fetal life
• AFP expression in adults is often associated with hepatoma or teratoma
• However, hereditary persistence of AFP may also be found in individuals with no obvious pathology
• The protein is thought to be the fetal counterpart of serum albumin, and AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4
• AFP is found in monomeric, dimeric, and trimeric forms
• AFP can also bind to copper ions, nickel ions, fatty acids and bilirubin
• The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly
• High level of serum AFP has been identified in patients with hepatocellular carcinomas (HCC), teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.