Rovalpituzumab Recombinant Human Monoclonal Antibody, Invitrogen™

Description

• Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles
• Store at 2 to 8 °C for one week
• Store at -20 to -80 °C for twelve months from the date of receipt
• Rovalpituzumab is a biosimilar that targets DLL3
• Delta-like protein 3 (DLL3) is a ligand for the Notch signaling pathway
• It inhibits primary neurogenesis
• DLL3 plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm
• Defects in DLL3 are the cause of Spondylocostal dysostosis autosomal recessive type 1 (SCDO1)
• Mutations in DLL3 gene cause truncal shortening relative to their limbs, which leads to abdominal protrusion, abnormal spinal curvature and sometimes a plagiocephaly-torticollis sequence
• It may be required to divert neurons along a specific differentiation pathway.