Ranevetmab Recombinant Canine Monoclonal Antibody, Invitrogen™

Description

• Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles
• Store at 2 to 8 °C for one week
• Store at -20 to -80 °C for twelve months from the date of receipt
• Ranevetmab is a biosimilar that targets NGF
• Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells
• The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites
• Although both types of receptor bind NGF only the high affinity form is capable of signal transduction
• Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex
• Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species
• NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons
• Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons
• Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.