Sirtratumab Recombinant Human Monoclonal Antibody, Invitrogen™

Description

• Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles
• Store at 2 to 8 °C for one week
• Store at -20 to -80 °C for twelve months from the date of receipt
• Sirtratumab is a biosimilar that targets SLITRK6
• SLIT and NTRK-like family 6 (Slitrk6) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein
• These proteins are also homologous to trk neurotrophin receptors in their intracellular domains
• Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family
• Slitrk6 expression has been observed in tissues such as tongue, lung, gastrointestinal tract, and pancreas
• Like every other Slitrk protein except Slitrk1, overexpression of Slitrk6 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth
• At least two isoforms of Slitrk6 are known to exisit.