Enapotamab Recombinant Human Monoclonal Antibody, Invitrogen™

Description

• Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles
• Store at 2 to 8 °C for one week
• Store at -20 to -80 °C for twelve months from the date of receipt
• Enapotamab is a biosimilar that targets AXL
• Axl is a member of the TAM receptor family, which also includes also MerTK and TYRO3
• Axl contains protein kinase activity and is activated by dimerization and auto-phosphorylation upon ligand binding
• In response to its ligands, Protein S and GAS6, Axl activates anti-inflammatory pathways (through SOCS-1 and SOCS-3), which limits TLR and cytokine signaling
• This results in dampened inflammatory responses in macrophages and DCs
• TAM receptors are also involved in phagocytosis of apoptotic cells
• Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies
• In addition, Axl may function as a putative entry receptor for filoviruses
• Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells
• Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C
• Soluble Axl is generated by proteolytic cleavage of the membrane form
• Increased plasma levels may be indicative of inflammation and cancer.