Gatralimab Recombinant Human Monoclonal Antibody, Invitrogen™

Description

• Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles
• Store at 2 to 8 °C for one week
• Store at -20 to -80 °C for twelve months from the date of receipt
• Gatralimab is a biosimilar that targets CD52
• Human CD52, also known as Cambridge pathology antigen 1 (CAMPATH-1), is a glycoprotein found in the male reproductive tract and immune cells
• It is abundantly expressed on the surface of nearly all human peripheral blood lymphocytes
• The CD52 antigen is Gpi-anchored membrane receptor that consists of a small 12 amino acid peptide attached to a large N-linked carbohydrate group
• CD52 is a potent target for inducing cytolysis of mature lymphocytes
• Alemtuzumab, a humanized monoclonal antibody targeting CD52, is used as an immunomodulatory drug for the treatment of chronic lymphocytic leukemia, T cell lymphomas, multiple sclerosis, and other diseases.