PIMA542640
MCL-1 Recombinant Rabbit Monoclonal Antibody (4F3W1), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA542640-Each-of-1 | In Stock | ₹ 44,020.62 |
PIMA542640 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,020.62
GST (18%): ₹ 7,923.712
Total Price: ₹ 51,944.332
Antigen
MCL-1
Classification
Recombinant Monoclonal
Concentration
1.56 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P97287, Q07820, Q9Z1P3
Gene Symbols
MCL1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MCL1 (Q07820).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
4F3W1
Conjugate
Unconjugated
Gene
MCL1
Gene Alias
AW556805; BCL2 family apoptosis regulator; BCL2L3; bcl2-L-3; Bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Mcl1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; MCL-1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); TM
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17210, 4170, 60430
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- The target is usually found in the following locations: Cytoplasm, Membrane, Mitochondrion, Nucleus, Single-pass membrane protein, nucleoplasm
- Immunogen sequence: GGEAGAVIGG SAGASPPSTL TPDSRRVARP PPIGAEVPDV TATPARLLFF APTRRAAPLE EMEAPAADAI MSPEEELDGY EPEPLGKRPA VLPLLELVGE S MCL1 (Myeloid cell leukemia-1) belongs to the Bcl-2 family and is involved in programing, differentiation and concomitant maintenance of cell viability, but not of proliferation
- Isoform 1 of MCL1 inhibits apoptosis while isoform 2 promotes it
- The carboxy terminal of MCL1 and bcl-2 share significant sequence homology
- Expression of MCL1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g
- ionizing radiation, μgtraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2
- Enhanced expression of MCL1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation
- Like bcl-2, MCL1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis
- While the mechanism by which MCL1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak
- MCL1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types
- MCL1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals
- MCL1 exists as at least two distinct isoforms designated MCL1L and MCL1S
- In marked contrast to the larger isoform of MCL1, overexpression of MCL1S promotes cell death.
Compare Similar Items
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Antigen: MCL-1
Classification: Recombinant Monoclonal
Concentration: 1.56 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P97287, Q07820, Q9Z1P3
Gene Symbols: MCL1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MCL1 (Q07820).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 4F3W1
Conjugate: Unconjugated
Gene: MCL1
Gene Alias: AW556805; BCL2 family apoptosis regulator; BCL2L3; bcl2-L-3; Bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Mcl1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; MCL-1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); TM
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17210, 4170, 60430
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
MCL-1
Classification:
Recombinant Monoclonal
Concentration:
1.56 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P97287, Q07820, Q9Z1P3
Gene Symbols:
MCL1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MCL1 (Q07820).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
4F3W1
Conjugate:
Unconjugated
Gene:
MCL1
Gene Alias:
AW556805; BCL2 family apoptosis regulator; BCL2L3; bcl2-L-3; Bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Mcl1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; MCL-1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); TM
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17210, 4170, 60430
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Active Caspase 3
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: P42574
Gene Symbols: CASP3
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CASP3 (P42574)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: 3J2A1
Conjugate: Unconjugated
Gene: CASP3
Gene Alias: A830040C14Rik; AC-3; Apopain; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; CC3; CPP32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; IRP; Lice; mLdy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 836
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Active Caspase 3
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
P42574
Gene Symbols:
CASP3
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CASP3 (P42574)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
3J2A1
Conjugate:
Unconjugated
Gene:
CASP3
Gene Alias:
A830040C14Rik; AC-3; Apopain; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; CC3; CPP32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; IRP; Lice; mLdy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
836
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: NGAL
Classification: Recombinant Monoclonal
Concentration: 0.75 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P80188
Gene Symbols: LCN2
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Lipocalin-2/NGAL (P80188).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: 1M2R3
Conjugate: Unconjugated
Gene: LCN2
Gene Alias: 24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; alpha-2-microglobulin-related protein; Alpha-2U globulin-related protein; AW212229; HGNC:6526; HNL; LCN2; lipocalin 2; lipocalin 2 (oncogene 24p3); Lipocalin 24p3; Lipocalin2; Lipocalin-2; migration-stimulating factor inhibitor; MSFI; neutrophil gelatinase-associated lipocalin; NGAL; oncogene 24p3; OTTHUMP00000022240; p25; RP23-161B9.11; secreted inducible protein 24; Siderocalin; Siderocalin LCN2; Sip24; SV-40-induced 24P3 protein; uterocalin
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3934
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
NGAL
Classification:
Recombinant Monoclonal
Concentration:
0.75 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P80188
Gene Symbols:
LCN2
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Lipocalin-2/NGAL (P80188).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
1M2R3
Conjugate:
Unconjugated
Gene:
LCN2
Gene Alias:
24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; alpha-2-microglobulin-related protein; Alpha-2U globulin-related protein; AW212229; HGNC:6526; HNL; LCN2; lipocalin 2; lipocalin 2 (oncogene 24p3); Lipocalin 24p3; Lipocalin2; Lipocalin-2; migration-stimulating factor inhibitor; MSFI; neutrophil gelatinase-associated lipocalin; NGAL; oncogene 24p3; OTTHUMP00000022240; p25; RP23-161B9.11; secreted inducible protein 24; Siderocalin; Siderocalin LCN2; Sip24; SV-40-induced 24P3 protein; uterocalin
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3934
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Sodium Potassium ATPase
Classification: Recombinant Monoclonal
Concentration: 0.8 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P05023, P06685, Q13733, Q64541, Q8VDN2, Q9WV27
Gene Symbols: ATP1A1, ATP1A4
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Na+/K+-ATPase (P05023).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: 3L6F0
Conjugate: Unconjugated
Gene: ATP1A4
Gene Alias: ATP1A1; ATP1A4; ATP1AL2; Atpa-1; ATPase Na+/K+ transporting subunit alpha 1; ATPase Na+/K+ transporting subunit alpha 4; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+/K+ transporting, alpha 4 polypeptide; ATPase, Na+/K+ transporting, alpha polypeptide-like 2; ATPase, Na+K+ transporting, alpha 1; BC010319; Na(+)/K(+) ATPase alpha-1 subunit; Na(+)/K(+) ATPase alpha-4 subunit; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; Na,K-ATPase subunit alpha-C; Na+/K+ ATPase 1; Na+/K+ ATPase 4; Na+/K+ ATPase alpha 4 subunit; Na+/K+ ATPase, alpha-D polypeptide; Nkaa1b; sodium pump 4; sodium pump subunit alpha-1; Sodium pump subunit alpha-4; sodium/potassium-transporting ATPase alpha-4 chain; sodium/potassium-transporting ATPase subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-4; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-4; sodium-potassium-ATPase, alpha 1 polypeptide
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11928, 24211, 27222, 29132, 476, 480
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Sodium Potassium ATPase
Classification:
Recombinant Monoclonal
Concentration:
0.8 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P05023, P06685, Q13733, Q64541, Q8VDN2, Q9WV27
Gene Symbols:
ATP1A1, ATP1A4
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Na+/K+-ATPase (P05023).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
3L6F0
Conjugate:
Unconjugated
Gene:
ATP1A4
Gene Alias:
ATP1A1; ATP1A4; ATP1AL2; Atpa-1; ATPase Na+/K+ transporting subunit alpha 1; ATPase Na+/K+ transporting subunit alpha 4; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+/K+ transporting, alpha 4 polypeptide; ATPase, Na+/K+ transporting, alpha polypeptide-like 2; ATPase, Na+K+ transporting, alpha 1; BC010319; Na(+)/K(+) ATPase alpha-1 subunit; Na(+)/K(+) ATPase alpha-4 subunit; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; Na,K-ATPase subunit alpha-C; Na+/K+ ATPase 1; Na+/K+ ATPase 4; Na+/K+ ATPase alpha 4 subunit; Na+/K+ ATPase, alpha-D polypeptide; Nkaa1b; sodium pump 4; sodium pump subunit alpha-1; Sodium pump subunit alpha-4; sodium/potassium-transporting ATPase alpha-4 chain; sodium/potassium-transporting ATPase subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-4; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-4; sodium-potassium-ATPase, alpha 1 polypeptide
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11928, 24211, 27222, 29132, 476, 480
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid