PIMA544561
EGFR L858R Recombinant Rabbit Monoclonal Antibody (RM380), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544561-Each-of-1 | In Stock | ₹ 38,416.44 |
PIMA544561 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,416.44
GST (18%): ₹ 6,914.959
Total Price: ₹ 45,331.399
Antigen
EGFR L858R
Classification
Recombinant Monoclonal
Concentration
100 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
P00533
Gene Symbols
EGFR
Immunogen
A peptide corresponding to human EGFR (L858R Mutant Specific). The immunogen range is a synthetic peptide within to amino acids 800-900 of EGFR with L858R mutant.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
RM380
Conjugate
Unconjugated
Gene
EGFR
Gene Alias
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EGFR, Epidermal growth factor receptor, ERBB, ERBB1, erb-b2 receptor tyrosine kinase 1, HER1, mENA, NISBD2, PIG61, proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1956
Content And Storage
-20°C
Isotype
IgG
Description
- EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans
- EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4
- EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain
- Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase
- EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells
- Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway
- Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling
- Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found
- Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors
- Moreover, EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma
- This product is specific for EGFR (mutant L858R).
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Antigen: EGFR L858R
Classification: Recombinant Monoclonal
Concentration: 100 μg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: P00533
Gene Symbols: EGFR
Immunogen: A peptide corresponding to human EGFR (L858R Mutant Specific). The immunogen range is a synthetic peptide within to amino acids 800-900 of EGFR with L858R mutant.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: RM380
Conjugate: Unconjugated
Gene: EGFR
Gene Alias: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EGFR, Epidermal growth factor receptor, ERBB, ERBB1, erb-b2 receptor tyrosine kinase 1, HER1, mENA, NISBD2, PIG61, proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 1956
Content And Storage: -20°C
Isotype: IgG
Antigen:
EGFR L858R
Classification:
Recombinant Monoclonal
Concentration:
100 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
P00533
Gene Symbols:
EGFR
Immunogen:
A peptide corresponding to human EGFR (L858R Mutant Specific). The immunogen range is a synthetic peptide within to amino acids 800-900 of EGFR with L858R mutant.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
RM380
Conjugate:
Unconjugated
Gene:
EGFR
Gene Alias:
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EGFR, Epidermal growth factor receptor, ERBB, ERBB1, erb-b2 receptor tyrosine kinase 1, HER1, mENA, NISBD2, PIG61, proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
1956
Content And Storage:
-20°C
Isotype:
IgG
Antigen: H3.3 G34R oncohistone mutant
Classification: Recombinant Monoclonal
Concentration: 250 μg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: P84243
Gene Symbols: H3-3A, H3-3B
Immunogen: A peptide corresponding to Histone H3.3 G34R mutant. The immunogen range is a synthetic peptide within amino acids 1-100 of histone H3.3 with G34R mutant.
Quantity: 50 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: RM240
Conjugate: Biotin
Gene: H3-3A
Gene Alias: H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B), H3.3, H3.3 G34R, H3.3A, H3.3B, H3/g, H3-3A, H3-3B, H3B, H3F3, H3F3A, H3F3B, H3FT, H3t, Histone 3.3, Histone cluster 3, Histone H3, Histone H3.3, Histone H3.3 G34R, Histone H3.3G34R, PP781
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 3020, 3021
Content And Storage: -20°C
Isotype: IgG
Antigen:
H3.3 G34R oncohistone mutant
Classification:
Recombinant Monoclonal
Concentration:
250 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
P84243
Gene Symbols:
H3-3A, H3-3B
Immunogen:
A peptide corresponding to Histone H3.3 G34R mutant. The immunogen range is a synthetic peptide within amino acids 1-100 of histone H3.3 with G34R mutant.
Quantity:
50 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
RM240
Conjugate:
Biotin
Gene:
H3-3A
Gene Alias:
H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B), H3.3, H3.3 G34R, H3.3A, H3.3B, H3/g, H3-3A, H3-3B, H3B, H3F3, H3F3A, H3F3B, H3FT, H3t, Histone 3.3, Histone cluster 3, Histone H3, Histone H3.3, Histone H3.3 G34R, Histone H3.3G34R, PP781
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
3020, 3021
Content And Storage:
-20°C
Isotype:
IgG
Antigen: H3 K36M oncohistone mutant
Classification: Recombinant Monoclonal
Concentration: 250 μg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: P68431, Q71DI3
Gene Symbols: H3C1, H3C10, H3C12, H3C14, H3C15, H3C2, H3C7
Immunogen: A peptide corresponding to Histone H3 K36M mutant. The immunogen range is a synthetic peptide within amino acids 1-100 of histone H3 with K36M mutant.
Quantity: 50 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: RM193
Conjugate: Biotin
Gene: H3C1
Gene Alias: H3, H3 histone, H3 histone family, member A, H3 histone family, member I, H3 histone family, member K, H3 histone family, member L, H3 histone family, member M, H3 histone, family 2, H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B), H3 histone, family 3C, H3 K36, H3 K36M, H3.2, H3.3A, H3.3B, H3.5, H3/A, H3/b, H3/d, H3/f, H3/i, H3/j, H3/k, H3/l, H3/M, H3/n, H3/o, H3-3A, H3-3B, H3a, H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3F1K, H3F2, H3F3, H3F3A, H3F3B, H3F3C, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, H3FM, H3FN, H3K36 mutant, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HIST2H3A, HIST2H3C, HIST2H3D, histone 1, H3a, histone 1, H3b, histone 1, H3f, histone 1, H3h, histone 2, H3a, histone 2, H3c, Histone 3, histone cluster 1, H3a, histone cluster 1, H3b, histone cluster 1, H3f, histone cluster 1, H3h, histone cluster 2, H3a, histone cluster 2, H3c, Histone H3, Histone H3 K36M, histone H3.1, Histone H3.2, histone H3.3, Histone H3.3C, histone H3.5, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, histone H3/l, Histone H3/m, histone H3/o, Histone H3K36M, histone variant H3.5, PP781
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 126961, 333932, 8350, 8356, 8357, 8358, 8968
Content And Storage: -20°C
Isotype: IgG
Antigen:
H3 K36M oncohistone mutant
Classification:
Recombinant Monoclonal
Concentration:
250 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
P68431, Q71DI3
Gene Symbols:
H3C1, H3C10, H3C12, H3C14, H3C15, H3C2, H3C7
Immunogen:
A peptide corresponding to Histone H3 K36M mutant. The immunogen range is a synthetic peptide within amino acids 1-100 of histone H3 with K36M mutant.
Quantity:
50 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
RM193
Conjugate:
Biotin
Gene:
H3C1
Gene Alias:
H3, H3 histone, H3 histone family, member A, H3 histone family, member I, H3 histone family, member K, H3 histone family, member L, H3 histone family, member M, H3 histone, family 2, H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B), H3 histone, family 3C, H3 K36, H3 K36M, H3.2, H3.3A, H3.3B, H3.5, H3/A, H3/b, H3/d, H3/f, H3/i, H3/j, H3/k, H3/l, H3/M, H3/n, H3/o, H3-3A, H3-3B, H3a, H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3F1K, H3F2, H3F3, H3F3A, H3F3B, H3F3C, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, H3FM, H3FN, H3K36 mutant, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HIST2H3A, HIST2H3C, HIST2H3D, histone 1, H3a, histone 1, H3b, histone 1, H3f, histone 1, H3h, histone 2, H3a, histone 2, H3c, Histone 3, histone cluster 1, H3a, histone cluster 1, H3b, histone cluster 1, H3f, histone cluster 1, H3h, histone cluster 2, H3a, histone cluster 2, H3c, Histone H3, Histone H3 K36M, histone H3.1, Histone H3.2, histone H3.3, Histone H3.3C, histone H3.5, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, histone H3/l, Histone H3/m, histone H3/o, Histone H3K36M, histone variant H3.5, PP781
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
126961, 333932, 8350, 8356, 8357, 8358, 8968
Content And Storage:
-20°C
Isotype:
IgG
Antigen: H3.3 K4M oncohistone mutant
Classification: Recombinant Monoclonal
Concentration: 250 μg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: P84243
Gene Symbols: H3-3A, H3-3B
Immunogen: A peptide corresponding to Histone H3 K4M mutant. The immunogen range is a synthetic peptide within amino acids 1-100 of histone H3 with K4M mutant.
Quantity: 50 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: RM363
Conjugate: Biotin
Gene: H3-3A
Gene Alias: H3, H3 histone family, member A, H3 histone family, member I, H3 histone family, member K, H3 histone family, member L, H3 histone family, member M, H3 histone, family 2, H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B), H3 histone, family 3C, H3 K4, H3 K4M, H3.1-221, H3.1-291, H3.1-I, H3.2, H3.2-221, H3.2-614, H3.2-615, H3.2-616, H3.3A, H3.3B, H3.5, H3/A, H3/b, H3/d, H3/f, H3/i, H3/j, H3/k, H3/l, H3/M, H3/n, H3/o, H3-143, H3-291, H3-3A, H3-3b, H3-53, H3-614, H3a, H3b, H3-B, H3c1, H3c10, H3c11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3f, H3-F, H3F1K, H3F2, H3F3, H3F3A, H3f3b, H3F3C, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, H3FM, H3FN, H3g, H3h, H3i, H3K4 mutant, H3K4M, Hist1, HIST1H3A, HIST1H3B, Hist1h3c, HIST1H3D, Hist1h3e, Hist1h3f, HIST1H3G, Hist1h3h, Hist1h3i, HIST1H3J, HIST2H3A, Hist2h3b, HIST2H3C, Hist2h3c1, Hist2h3c2, Hist2h3c2-ps, Hist2h3ca1, Hist2h3ca2, HIST2H3D, histone 1, H3a, histone 1, H3b, histone 1, H3f, histone 1, H3h, histone 2, H3a, histone 2, H3c, histone 2, H3c2, histone 2, H3ca2, Histone 3, histone cluster 1, H3a, histone cluster 1, H3b, histone cluster 1, H3f, histone cluster 1, H3h, histone cluster 2, H3a, histone cluster 2, H3c, histone cluster 2, H3c2, histone cluster 2, H3c2, pseudogene, histone gene complex 1, histone H3, Histone H3 K4M, histone H3.1, Histone H3.2, histone H3.3, Histone H3.3C, histone H3.5, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, histone H3/l, Histone H3/m, histone H3/o, Histone H3K4M, histone variant H3.5, M32461, PP781
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 3020, 3021
Content And Storage: -20°C
Isotype: IgG
Antigen:
H3.3 K4M oncohistone mutant
Classification:
Recombinant Monoclonal
Concentration:
250 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
P84243
Gene Symbols:
H3-3A, H3-3B
Immunogen:
A peptide corresponding to Histone H3 K4M mutant. The immunogen range is a synthetic peptide within amino acids 1-100 of histone H3 with K4M mutant.
Quantity:
50 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
RM363
Conjugate:
Biotin
Gene:
H3-3A
Gene Alias:
H3, H3 histone family, member A, H3 histone family, member I, H3 histone family, member K, H3 histone family, member L, H3 histone family, member M, H3 histone, family 2, H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B), H3 histone, family 3C, H3 K4, H3 K4M, H3.1-221, H3.1-291, H3.1-I, H3.2, H3.2-221, H3.2-614, H3.2-615, H3.2-616, H3.3A, H3.3B, H3.5, H3/A, H3/b, H3/d, H3/f, H3/i, H3/j, H3/k, H3/l, H3/M, H3/n, H3/o, H3-143, H3-291, H3-3A, H3-3b, H3-53, H3-614, H3a, H3b, H3-B, H3c1, H3c10, H3c11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3f, H3-F, H3F1K, H3F2, H3F3, H3F3A, H3f3b, H3F3C, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, H3FM, H3FN, H3g, H3h, H3i, H3K4 mutant, H3K4M, Hist1, HIST1H3A, HIST1H3B, Hist1h3c, HIST1H3D, Hist1h3e, Hist1h3f, HIST1H3G, Hist1h3h, Hist1h3i, HIST1H3J, HIST2H3A, Hist2h3b, HIST2H3C, Hist2h3c1, Hist2h3c2, Hist2h3c2-ps, Hist2h3ca1, Hist2h3ca2, HIST2H3D, histone 1, H3a, histone 1, H3b, histone 1, H3f, histone 1, H3h, histone 2, H3a, histone 2, H3c, histone 2, H3c2, histone 2, H3ca2, Histone 3, histone cluster 1, H3a, histone cluster 1, H3b, histone cluster 1, H3f, histone cluster 1, H3h, histone cluster 2, H3a, histone cluster 2, H3c, histone cluster 2, H3c2, histone cluster 2, H3c2, pseudogene, histone gene complex 1, histone H3, Histone H3 K4M, histone H3.1, Histone H3.2, histone H3.3, Histone H3.3C, histone H3.5, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, histone H3/l, Histone H3/m, histone H3/o, Histone H3K4M, histone variant H3.5, M32461, PP781
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
3020, 3021
Content And Storage:
-20°C
Isotype:
IgG