PIMA544588
SMAD4 Recombinant Rabbit Monoclonal Antibody (RM277), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544588-Each-of-1 | In Stock | ₹ 38,416.44 |
PIMA544588 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,416.44
GST (18%): ₹ 6,914.959
Total Price: ₹ 45,331.399
Antigen
SMAD4
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
O70437, P97471, Q13485
Gene Symbols
SMAD4
Immunogen
A peptide corresponding to the C-terminus of human Smad4.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
RM277
Conjugate
Unconjugated
Gene
SMAD4
Gene Alias
AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
17128, 4089, 50554
Content And Storage
-20°C
Isotype
IgG
Related Products
Description
- This antibody reacts to 5-Carboxylcytosine in DNA
- No cross reactivity with non-modified cytosine and other modified cytosines in DNA
- Smad4 is encoded by the Smad4 gene that is located on chromosome 18 in humans
- Smad4 is also known as Smad family member 4, Sma- and Mad-related protein 4 or Mothers against decapentaplegic (MAD) homolog 4
- Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) globular domains that are involved in DNA binding and protein interactions respectively
- Binding of the TGF-beta superfamily of ligands that includes Transforming Growth Factor -beta (TGF-beta) and bone morphogenetic protein (BMP) to its cognate receptor allows phosphorylation of Smad 1, 2, 3, 5 and 8 (R-Smad, Receptor Smad)
- This signals for heterotrimerization with Smad4 (co-Smad, co-mediator Smad) and translocation of the complex to the nucleus
- Inhibitory or antagonistic Smad (I-Smad) that includes Smad 6 and 7, interact with activated R-Smads and attenuate the signaling pathway
- Smad4 acts as a tumor suppressor protein by transcriptionally regulating its target genes such as Cyclin D1 (downregulation) and collagen (upregulation) that inhibit cell proliferation
- Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.
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Antigen: SMAD4
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: O70437, P97471, Q13485
Gene Symbols: SMAD4
Immunogen: A peptide corresponding to the C-terminus of human Smad4.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: RM277
Conjugate: Unconjugated
Gene: SMAD4
Gene Alias: AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 17128, 4089, 50554
Content And Storage: -20°C
Isotype: IgG
Antigen:
SMAD4
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
O70437, P97471, Q13485
Gene Symbols:
SMAD4
Immunogen:
A peptide corresponding to the C-terminus of human Smad4.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
RM277
Conjugate:
Unconjugated
Gene:
SMAD4
Gene Alias:
AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
17128, 4089, 50554
Content And Storage:
-20°C
Isotype:
IgG
Antigen: Nkx3.1
Classification: Recombinant Monoclonal
Concentration: 400 μg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: Q99801
Gene Symbols: NKX3-1
Immunogen: A peptide corresponding to the N-terminus of human Nkx3.1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Clone: RM430
Conjugate: Unconjugated
Gene: NKX3-1
Gene Alias: bagpipe, BAPX2, Bax, Drosophila NK-3 transcription factor, locus 1, homeobox protein NK-3 homolog A, Homeobox protein Nkx-3.1, NK homeobox, family 3, A, NK3 homeobox 1, NK3 transcription factor homolog A, NK3 transcription factor related, locus 1, NK-3 transcription factor, locus 1, NK-3 transcription factor, locus 1 (Drosophila), NKX3, NKX3.1, Nkx-3.1, Nkx3-1, NKX3-1 antibody, NKX3A, prostate-specific ag
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 4824
Content And Storage: -20°C
Isotype: IgG
Antigen:
Nkx3.1
Classification:
Recombinant Monoclonal
Concentration:
400 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
Q99801
Gene Symbols:
NKX3-1
Immunogen:
A peptide corresponding to the N-terminus of human Nkx3.1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Clone:
RM430
Conjugate:
Unconjugated
Gene:
NKX3-1
Gene Alias:
bagpipe, BAPX2, Bax, Drosophila NK-3 transcription factor, locus 1, homeobox protein NK-3 homolog A, Homeobox protein Nkx-3.1, NK homeobox, family 3, A, NK3 homeobox 1, NK3 transcription factor homolog A, NK3 transcription factor related, locus 1, NK-3 transcription factor, locus 1, NK-3 transcription factor, locus 1 (Drosophila), NKX3, NKX3.1, Nkx-3.1, Nkx3-1, NKX3-1 antibody, NKX3A, prostate-specific ag
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
4824
Content And Storage:
-20°C
Isotype:
IgG
Antigen: Synaptophysin
Classification: Recombinant Monoclonal
Concentration: 40 μg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: P08247
Gene Symbols: Syp
Immunogen: A peptide corresponding to the C-terminus of Synaptophysin.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: RM258
Conjugate: Unconjugated
Gene: Syp
Gene Alias: A230093K24Rik, AI848995, BM89 antigen, I79_012252, Major synaptic vesicle protein p38, MRX96, MRXSYP, p38, Syn, Synaptophysin, Syp, Syp I, Syp1
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 6855
Content And Storage: -20°C
Isotype: IgG
Antigen:
Synaptophysin
Classification:
Recombinant Monoclonal
Concentration:
40 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
P08247
Gene Symbols:
Syp
Immunogen:
A peptide corresponding to the C-terminus of Synaptophysin.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
RM258
Conjugate:
Unconjugated
Gene:
Syp
Gene Alias:
A230093K24Rik, AI848995, BM89 antigen, I79_012252, Major synaptic vesicle protein p38, MRX96, MRXSYP, p38, Syn, Synaptophysin, Syp, Syp I, Syp1
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
6855
Content And Storage:
-20°C
Isotype:
IgG
Antigen: De-tyrosinated alpha Tubulin
Classification: Recombinant Monoclonal
Concentration: 100 μg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: Q71U36
Gene Symbols: TUBA1A
Immunogen: A peptide corresponding to human dTyr a-tubulin. The immunogen range is a synthetic peptide within amino acids 351-451 of human alpha Tubulin which lacks a carboxy-terminal tyrosine group.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Clone: RM444
Conjugate: Unconjugated
Gene: TUBA1A
Gene Alias: __
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 7846
Content And Storage: -20°C
Isotype: IgG
Antigen:
De-tyrosinated alpha Tubulin
Classification:
Recombinant Monoclonal
Concentration:
100 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
Q71U36
Gene Symbols:
TUBA1A
Immunogen:
A peptide corresponding to human dTyr a-tubulin. The immunogen range is a synthetic peptide within amino acids 351-451 of human alpha Tubulin which lacks a carboxy-terminal tyrosine group.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Clone:
RM444
Conjugate:
Unconjugated
Gene:
TUBA1A
Gene Alias:
__
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
7846
Content And Storage:
-20°C
Isotype:
IgG