PIMA544656

c-Kit Recombinant Rabbit Monoclonal Antibody (PD00-24), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIMA544656-Each-of-1 In Stock ₹ 41,068.80

PIMA544656 - Each of 1

₹ 41,068.80

In Stock

Quantity

1

Base Price: ₹ 41,068.80

GST (18%): ₹ 7,392.384

Total Price: ₹ 48,461.184

Antigen

c-Kit

Classification

Recombinant Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4

Gene Accession No.

P10721

Gene Symbols

KIT

Immunogen

Recombinant protein within human CD117/c-Kit aa 25-295.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Form

Liquid

Applications

Immunohistochemistry (Paraffin)

Clone

PD00-24

Conjugate

Unconjugated

Gene

KIT

Gene Alias

belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W

Host Species

Rabbit

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

3815

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Isotype

IgG

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Description

  • KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor)
  • KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit
  • KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells
  • Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism
  • Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth
  • c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells
  • Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor
  • This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway
  • SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT
  • c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

Compare Similar Items

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Img

Thermo Scientific

PIMA544656

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Antigen:
c-Kit

Classification:
Recombinant Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4

Gene Accession No.:
P10721

Gene Symbols:
KIT

Immunogen:
Recombinant protein within human CD117/c-Kit aa 25-295.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin)

Clone:
PD00-24

Conjugate:
Unconjugated

Gene:
KIT

Gene Alias:
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W

Host Species:
Rabbit

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
3815

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Isotype:
IgG

Img

Thermo Scientific

PIMA544658

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Antigen:
N6-Methyladenosine (m6A)

Classification:
Recombinant Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
m6A Small Molecule conjugated to OVA.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Chemical

Form:
Liquid

Applications:
Dot Blot, ELISA

Clone:
1G1

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
C11H15N5O4; m6A

Host Species:
Rabbit

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Isotype:
IgG

Img

Thermo Scientific

PIMA544659

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Antigen:
Placental Alkaline Phosphatase

Classification:
Recombinant Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4

Gene Accession No.:
P05187

Gene Symbols:
ALPP

Immunogen:
Recombinant fragment within Human Placental alkaline phosphatase (PLAP) aa 150-300.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Clone:
PD00-19

Conjugate:
Unconjugated

Gene:
ALPP

Gene Alias:
Alkaline phosphatase placental type; Alkaline phosphatase Regan isozyme; alkaline phosphatase, placental; alkaline phosphatase, placental type; alkaline phosphomonoesterase; ALP; Alp1; ALPP; AP-TNAP; DOA1; FLJ11281; FLJ40094; FLJ61142; FLJ93059; Germ-cell alkaline phosphatase; glycerophosphatase; HOPS; MGC161443; MGC167935; nagao Isozyme; P PLAP; PALP; PLA2P; PLAA; placental alkaline phosphatase 1; placental heat-stable alkaline phosphatase; PLAP; PLAP1; PLAP-1; rCG23846-like; Regan isozyme; TNAP; TNSALP

Host Species:
Rabbit

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
250

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Isotype:
IgG

Img

Thermo Scientific

PIMA544660

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Antigen:
CD99

Classification:
Recombinant Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4

Gene Accession No.:
P14209

Gene Symbols:
CD99

Immunogen:
Synthetic peptide within human CD99 aa 148-185 (Cytoplasmic).

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin)

Clone:
PD00-13

Conjugate:
Unconjugated

Gene:
CD99

Gene Alias:
1110061M03Rik; 12E7; 2410026K10Rik; antigen identified by monoclonal 12E7, Y homolog; antigen identified by monoclonal antibodies 12E7, F21 and O13; Cd99; CD99 antigen; CD99 molecule; cell surface antigen 12E7; cell surface antigen HBA-71; cell surface antigen O13; D4; E2 antigen; HBA71; MIC2; MIC2 (monoclonal antibody 12E7); MIC2X; MIC2Y; MSK5X; paired immunoglobin-like type 2 receptor-ligand; pilr-1; Pilrl; PILR-L; Protein MIC2; surface antigen MIC2; T-cell surface glycoprotein E2

Host Species:
Rabbit

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
4267

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Isotype:
IgG