PIMA545974
Phospho-CHK1 (Ser345) Recombinant Rabbit Monoclonal Antibody (PS01-17), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA545974-Each-of-1 | In Stock | ₹ 37,218.60 |
PIMA545974 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,218.60
GST (18%): ₹ 6,699.348
Total Price: ₹ 43,917.948
Antigen
Phospho-CHK1 (Ser345)
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide
Gene Accession No.
O14757
Gene Symbols
Chek1
Immunogen
Synthetic peptide.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Clone
PS01-17
Conjugate
Unconjugated
Gene
Chek1
Gene Alias
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1111
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Predicted band size: 54 kDa Positive Control: HeLa treated with Etoposide cell lysate, HeLa treated with Hydroxyurea cell lysate, HeLa treated with 4mM Hydroxyurea for 20 hours
- Subcellular Location: Nucleus, Chromosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
- Sequence Similarities: 100% Mouse/Rat
- Tissue Specificity: Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon
- CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised
- CHK1 is a key mediator in the DNA damage-induced checkpoint network
- CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress
- When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase
- Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
Compare Similar Items
Show Difference
Antigen: Phospho-CHK1 (Ser345)
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide
Gene Accession No.: O14757
Gene Symbols: Chek1
Immunogen: Synthetic peptide.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Clone: PS01-17
Conjugate: Unconjugated
Gene: Chek1
Gene Alias: C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 1111
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG
Antigen:
Phospho-CHK1 (Ser345)
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide
Gene Accession No.:
O14757
Gene Symbols:
Chek1
Immunogen:
Synthetic peptide.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Clone:
PS01-17
Conjugate:
Unconjugated
Gene:
Chek1
Gene Alias:
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
1111
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgG
Antigen: RICTOR
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide
Gene Accession No.: Q6R327
Gene Symbols: Rictor
Immunogen: Recombinant protein within human RICTOR aa 1459-1708.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Flow Cytometry, Immunocytochemistry, Western Blot
Clone: 1D5
Conjugate: Unconjugated
Gene: Rictor
Gene Alias: 4921505C17Rik; 6030405M08Rik; AVO3; AVO3 homolog; AW492497; D530039E11Rik; DKFZp686B11164; Fyb; FYN binding protein; hAVO3; Kiaa1999; mAVO3; MGC39830; PIA; pianissimo; protein pianissimo; Rapamycin-insensitive companion of mTOR; rictor; RPTOR independent companion of MTOR complex 2; RPTOR independent companion of MTOR, complex 2; TORC2-specific protein AVO3
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 253260
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG
Antigen:
RICTOR
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide
Gene Accession No.:
Q6R327
Gene Symbols:
Rictor
Immunogen:
Recombinant protein within human RICTOR aa 1459-1708.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Flow Cytometry, Immunocytochemistry, Western Blot
Clone:
1D5
Conjugate:
Unconjugated
Gene:
Rictor
Gene Alias:
4921505C17Rik; 6030405M08Rik; AVO3; AVO3 homolog; AW492497; D530039E11Rik; DKFZp686B11164; Fyb; FYN binding protein; hAVO3; Kiaa1999; mAVO3; MGC39830; PIA; pianissimo; protein pianissimo; Rapamycin-insensitive companion of mTOR; rictor; RPTOR independent companion of MTOR complex 2; RPTOR independent companion of MTOR, complex 2; TORC2-specific protein AVO3
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
253260
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgG
Antigen: SETD1A
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide
Gene Accession No.: O15047
Gene Symbols: SETD1A
Immunogen: Recombinant protein within C terminal human SET1A.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: PH00-01
Conjugate: Unconjugated
Gene: SETD1A
Gene Alias: BC010250; Histone-lysine N-methyltransferase SETD1A; hSET1A; KIAA0339; KMT2F; Lysine N-methyltransferase 2F; mKIAA0339; mNSC1; non-selective cation channel 1; Nsccn1; SET domain containing 1A; SET domain-containing protein 1A; SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET1A; SETD1A
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 9739
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG
Antigen:
SETD1A
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide
Gene Accession No.:
O15047
Gene Symbols:
SETD1A
Immunogen:
Recombinant protein within C terminal human SET1A.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
PH00-01
Conjugate:
Unconjugated
Gene:
SETD1A
Gene Alias:
BC010250; Histone-lysine N-methyltransferase SETD1A; hSET1A; KIAA0339; KMT2F; Lysine N-methyltransferase 2F; mKIAA0339; mNSC1; non-selective cation channel 1; Nsccn1; SET domain containing 1A; SET domain-containing protein 1A; SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET1A; SETD1A
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
9739
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgG
Antigen: DEPDC6
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide
Gene Accession No.: Q570Y9, Q8TB45
Gene Symbols: DEPTOR
Immunogen: Recombinant protein within human DPTOR aa 1-300.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: PH00-03
Conjugate: Unconjugated
Gene: DEPTOR
Gene Alias: DEP domain containing 6; DEP domain containing MTOR interacting protein; DEP domain containing MTOR-interacting protein; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEP.6; Depdc6; DEPTOR; Kiaa4200; RGD1561030
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 314979, 64798, 97998
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG
Antigen:
DEPDC6
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide
Gene Accession No.:
Q570Y9, Q8TB45
Gene Symbols:
DEPTOR
Immunogen:
Recombinant protein within human DPTOR aa 1-300.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
PH00-03
Conjugate:
Unconjugated
Gene:
DEPTOR
Gene Alias:
DEP domain containing 6; DEP domain containing MTOR interacting protein; DEP domain containing MTOR-interacting protein; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEP.6; Depdc6; DEPTOR; Kiaa4200; RGD1561030
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
314979, 64798, 97998
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgG