TNFRSF14 Recombinant Rabbit Monoclonal Antibody (004), FITC, Invitrogen™

Description

• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF14 (HVEM) (Met1-Val202) and conjugated with FITC under optimum conditions, the unreacted FITC was removed
• Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity
• Protected from prolonged exposure to light
• Do not freeze! Sodium azide is toxic to cells and should be disposed of properly
• Flush with large volumes of water during disposal
• TNFRSF14 is a member of the TNF-receptor superfamily
• TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry
• Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism
• The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response
• Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses
• Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.