CD127 Recombinant Rabbit Monoclonal Antibody (001), FITC, Invitrogen™

Description

• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human CD127 (Met1-Gly236) and conjugated with FITC under optimum conditions, the unreacted FITC was removed
• Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity
• Protected from prolonged exposure to light
• Do not freeze! Sodium azide is toxic to cells and should be disposed of properly
• Flush with large volumes of water during disposal
• CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis
• The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer
• CD127 consists of an alpha chain and a gamma chain
• The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules
• CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells
• The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor
• Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.