Hepatitis B Virus X Monoclonal Antibody (1883), Invitrogen™

Description

• Specificity: Specific to HBx
• Non-reactive with human cells
• Purified preparations consist of >90% pure mouse monoclonal antibody which has been purified from ascites fluid by protein A chromatography
• The final preparation is formulated to a protein concentration of 100 μg/mL in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide
• Each vial contains 1.0 mL
• This product contains no stabilizing proteins and should be stored at 4C until ready for use
• Working dilution must be determined by the user
• Suggested starting ranges are 1:10-1:50 for ICC/IF and 1:20-1:200
• for ELISA
• The hepatitis B virus is an important cause of acute and chronic liver disease
• It is also the most common form of parenterally transmitted viral hepatitis
• The Hepatitis B X antigen is a 154 amino acid ∽17 kDa multifunctional protein involved in the development of liver chirrosis and hepatocellular carcinoma
• The virus is estimated to affect some 350 million people worldwide
• Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries
• Hepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus
• In some individuals the infection is not cleared and followed by persistent intracellular viral carriage that can lead to the development of hepatocelular carcinomas
• There are currently 400 million HBV carriers worldwide making HBV one of the most common human pathogens.