Calcineurin B Monoclonal Antibody (CN-A1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA549305-Each-of-1 | In Stock | ₹ 34,908.48 |
PIMA549305 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,908.48
GST (18%): ₹ 6,283.526
Total Price: ₹ 41,192.006
Antigen
Calcineurin B
Classification
Monoclonal
Concentration
0.5-1 mg/mL
Formulation
ascites diluted in 1.2% sodium acetate with 0.01MG sodium azide
Gene Accession No.
P63098, P63099, P63100
Gene Symbols
PPP3R1
Immunogen
Bovine brain calcineurin.
Regulatory Status
RUO
Gene ID (Entrez)
282321, 29748, 5534
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
CN-A1
Conjugate
Unconjugated
Gene
PPP3R1
Gene Alias
ALNB1; calcineurin B, type I (19kDa); calcineurin subunit B type 1; CALNB1; CaNB1; Cna2; Cnb; Cnb1; MCIP1; PP2B beta 1; PPP3R1; protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); protein phospatase 3, regulatory subunit B, alpha isoform,type 1; protein phosphatase 2B regulatory subunit 1; protein phosphatase 2B regulatory subunit B alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; protein phosphatase 3 regulatory subunit B alpha; Protein phosphatase 3 regulatory subunit B alpha isoform 1; protein phosphatase 3 regulatory subunit B, alpha; protein phosphatase 3, regulatory subunit B, alpha; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Human, Rat
Form
Lyophilized
Related Products
Description
- Adding 1 mL of PBS buffer will yield a concentration of 100 μg/mL
- Calcineurin is a Ser/Thr, calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway
- Calcineurin (also referred to as protein phosphatase 2B) is composed of two subunits; calcineurin A (CnA), a 60 kDa catalytic subunit which is highly homologous to protein phosphatases 1 and 2A; and a 19 kDa regulatory subunit, calcineurin B (CnB) which, like calmodulin, contains four EF-hand calcium binding sites
- Calcineurin-mediated dephosphorylation of the nuclear factor of activated T-cells (NF-AT) is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells
- The immunosuppressive drugs, cyclosporin A and FK506, when bound to the immunophilins, cyclophilin and FKBP respectively, inhibit dephosphorylation and activation of NF-AT by calcineurin
- This inhibition is caused by the immunosuppressant/immunophilin complex simultaneously binding to both CnA and CnB which does not inhibit the phosphatase activity of CnA, but rather blocks access of the substrate to the catalytic domain of CnA.
Compare Similar Items
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Antigen: Calcineurin B
Classification: Monoclonal
Concentration: 0.5-1 mg/mL
Formulation: ascites diluted in 1.2% sodium acetate with 0.01MG sodium azide
Gene Accession No.: P63098, P63099, P63100
Gene Symbols: PPP3R1
Immunogen: Bovine brain calcineurin.
Regulatory Status: RUO
Gene ID (Entrez): 282321, 29748, 5534
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG1
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: CN-A1
Conjugate: Unconjugated
Gene: PPP3R1
Gene Alias: ALNB1; calcineurin B, type I (19kDa); calcineurin subunit B type 1; CALNB1; CaNB1; Cna2; Cnb; Cnb1; MCIP1; PP2B beta 1; PPP3R1; protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); protein phospatase 3, regulatory subunit B, alpha isoform,type 1; protein phosphatase 2B regulatory subunit 1; protein phosphatase 2B regulatory subunit B alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; protein phosphatase 3 regulatory subunit B alpha; Protein phosphatase 3 regulatory subunit B alpha isoform 1; protein phosphatase 3 regulatory subunit B, alpha; protein phosphatase 3, regulatory subunit B, alpha; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Bovine, Human, Rat
Form: Lyophilized
Antigen: pan Keratin
Classification: Cocktail
Concentration: 100 μg/mL
Formulation: ascites diluted in 1.2% sodium acetate with 0.01MG sodium azide
Gene Accession No.: P11530, P11531, P11532
Gene Symbols: __
Immunogen: mixture of several monoclonal cytokeratin clones.
Regulatory Status: RUO
Gene ID (Entrez): 100355731, 13405, 1756, 24907
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG1, IgG2a
Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone: C-11+PCK-26+CY-90+KS-1A3+M20+A53-B/A2
Conjugate: Unconjugated
Gene: DMD
Gene Alias: CK1; Keratin-1; KRT1
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Rat
Form: Lyophilized
Antigen: Talin 2
Classification: Monoclonal
Concentration: 100 μg/mL
Formulation: ascites diluted in 1.2% sodium acetate with 0.01MG sodium azide
Gene Accession No.: Q71LX4, Q9Y4G6
Gene Symbols: Tln2
Immunogen: Purified chicken gizzard talin.
Regulatory Status: RUO
Gene ID (Entrez): 315776, 415374, 70549, 83660
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG1
Applications: Western Blot
Clone: 8d4
Conjugate: Unconjugated
Gene: Tln2
Gene Alias: 5730421P04Rik; AI507121; AI787438; AL118320; ILWEQ; KIAA0320; mKIAA0320; RGD1565416; talin 2; talin-2; TLN2
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Chicken, Human, Mouse, Rat
Form: Lyophilized
