Progesterone Monoclonal Antibody (3D8), Invitrogen™

Description

• Antibody tested in indirect ELISA Progesterone is the major progestational steroid, secreted primarily by the corpus luteum and the placenta
• Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors
• Progesterone acts on the uterus, the mammary glands and the brain
• It is required in embryo implantation, pregnancy maintenance, and the development of mammary tissue for milk production
• Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids
• Therapeutic progesterone is a synthetic form of the endogenous hormone progesterone
• This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites
• [National Center for Biotechnology Information
• PubChem Compound Database; CID=5994]