PIPA131438
Phospho-MDM2 (Ser185) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA131438-Each-of-1 | In Stock | ₹ 47,443.02 |
PIPA131438 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,443.02
GST (18%): ₹ 8,539.744
Total Price: ₹ 55,982.764
Antigen
Phospho-MDM2 (Ser185)
Classification
Polyclonal
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.
P23804, Q00987
Gene Symbols
MDM2
Immunogen
synthetic peptide HRKRRRSLSFDPSLGLCEL, corresponding to amino acids 177-198 of Mouse MDM2.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17246, 314856, 4193
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
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Antigen: Phospho-MDM2 (Ser185)
Classification: Polyclonal
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.: P23804, Q00987
Gene Symbols: MDM2
Immunogen: synthetic peptide HRKRRRSLSFDPSLGLCEL, corresponding to amino acids 177-198 of Mouse MDM2.
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17246, 314856, 4193
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Phospho-MDM2 (Ser185)
Classification:
Polyclonal
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
P23804, Q00987
Gene Symbols:
MDM2
Immunogen:
synthetic peptide HRKRRRSLSFDPSLGLCEL, corresponding to amino acids 177-198 of Mouse MDM2.
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17246, 314856, 4193
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: MSC
Classification: Polyclonal
Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.: O60682
Gene Symbols: MSC
Immunogen: Peptide with sequence PLKSDWNSLDGIIR, from C-Terminus of the protein sequence according to NP_005089
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Conjugate: Unconjugated
Gene: MSC
Gene Alias: ABF1; ABF-1; Activated B-cell factor 1; activated B-cell factor 1, homolog of mouse musculin; activated B-cell factor-1; bHLHa22; Class A basic helix-loop-helix protein 22; Msc; Musculin; myogenic repressor; Myor
Host Species: Goat
Purification Method: IgG fraction
Regulatory Status: RUO
Gene ID (Entrez): 9242
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
MSC
Classification:
Polyclonal
Formulation:
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.:
O60682
Gene Symbols:
MSC
Immunogen:
Peptide with sequence PLKSDWNSLDGIIR, from C-Terminus of the protein sequence according to NP_005089
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Conjugate:
Unconjugated
Gene:
MSC
Gene Alias:
ABF1; ABF-1; Activated B-cell factor 1; activated B-cell factor 1, homolog of mouse musculin; activated B-cell factor-1; bHLHa22; Class A basic helix-loop-helix protein 22; Msc; Musculin; myogenic repressor; Myor
Host Species:
Goat
Purification Method:
IgG fraction
Regulatory Status:
RUO
Gene ID (Entrez):
9242
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: GRB2
Classification: Polyclonal
Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.: P62993, P62994, Q60631
Gene Symbols: GRB2
Immunogen: Peptide with sequence PRNYVTPVNRNV, from C Terminus of the protein sequence according to NP_002077
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Porcine, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Gene: GRB2
Gene Alias: AA408164; abundant SRC homology; adapter protein GRB2; Adapter protein GRB2-A; ASH; ASH protein; EGFRBP-GRB2; epidermal growth factor receptor-binding protein GRB2; grb2; grb2.L; grb2-a; grb2-b; Grb3-3; growth factor receptor bound protein 2; growth factor receptor bound protein 2 L homeolog; growth factor receptor-bound protein 2; Growth factor receptor-bound protein 2-A; growth factor receptor-bound protein 3; HT027; hypothetical protein LOC535298; MST084; MSTP084; NCKAP2; OTTHUMP00000166097; OTTHUMP00000166098; protein Ash; SH2/SH3 adapter GRB2; SH2/SH3 adapter GRB2-A; SH2/SH3 adaptor Grb2; XELAEV_18044055mg
Host Species: Goat
Purification Method: IgG fraction
Regulatory Status: RUO
Gene ID (Entrez): 100192436, 14784, 2885, 81504
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
GRB2
Classification:
Polyclonal
Formulation:
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P62993, P62994, Q60631
Gene Symbols:
GRB2
Immunogen:
Peptide with sequence PRNYVTPVNRNV, from C Terminus of the protein sequence according to NP_002077
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Porcine, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Gene:
GRB2
Gene Alias:
AA408164; abundant SRC homology; adapter protein GRB2; Adapter protein GRB2-A; ASH; ASH protein; EGFRBP-GRB2; epidermal growth factor receptor-binding protein GRB2; grb2; grb2.L; grb2-a; grb2-b; Grb3-3; growth factor receptor bound protein 2; growth factor receptor bound protein 2 L homeolog; growth factor receptor-bound protein 2; Growth factor receptor-bound protein 2-A; growth factor receptor-bound protein 3; HT027; hypothetical protein LOC535298; MST084; MSTP084; NCKAP2; OTTHUMP00000166097; OTTHUMP00000166098; protein Ash; SH2/SH3 adapter GRB2; SH2/SH3 adapter GRB2-A; SH2/SH3 adaptor Grb2; XELAEV_18044055mg
Host Species:
Goat
Purification Method:
IgG fraction
Regulatory Status:
RUO
Gene ID (Entrez):
100192436, 14784, 2885, 81504
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: Dysadherin
Classification: Polyclonal
Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q96DB9
Gene Symbols: FXYD5
Immunogen: synthetic peptide GKCRQLSRLCRNHCR (Human).
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Conjugate: Unconjugated
Gene: FXYD5
Gene Alias: DYSAD; Dysadherin; EF-8; FXYD domain containing ion transport regulator 5; FXYD domain-containing ion transport regulator 5; FXYD5; HSPC113; Ion channel homolog RIC; IWU1; IWU-1; KCT1; keratinocytes associated transmembrane protein 1; OIT2; oncoprotein induced transcript 2; oncoprotein-induced protein 2; PRO6241; RIC; UNQ2561/PRO6241
Host Species: Goat
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 53827
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Dysadherin
Classification:
Polyclonal
Formulation:
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q96DB9
Gene Symbols:
FXYD5
Immunogen:
synthetic peptide GKCRQLSRLCRNHCR (Human).
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Conjugate:
Unconjugated
Gene:
FXYD5
Gene Alias:
DYSAD; Dysadherin; EF-8; FXYD domain containing ion transport regulator 5; FXYD domain-containing ion transport regulator 5; FXYD5; HSPC113; Ion channel homolog RIC; IWU1; IWU-1; KCT1; keratinocytes associated transmembrane protein 1; OIT2; oncoprotein induced transcript 2; oncoprotein-induced protein 2; PRO6241; RIC; UNQ2561/PRO6241
Host Species:
Goat
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
53827
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid