PIPA133021
ICAD Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA133021-Each-of-1 | In Stock | ₹ 50,565.96 |
PIPA133021 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,565.96
GST (18%): ₹ 9,101.873
Total Price: ₹ 59,667.833
Antigen
ICAD
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DFFA
Gene Alias
A330085O09Rik; DFF; DFF1; DFF35; Dff45; DFF-45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; RP23-121D17.3
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1676
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide; pH 7.4
Gene Accession No.
O00273
Gene Symbols
DFFA
Immunogen
Peptide: amino acids 313-331 from the C-terminus of human DFF
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis
- ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35
- Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional
- ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation
- In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD
- The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD
- In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone
- There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells
- Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.
Compare Similar Items
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Antigen: ICAD
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DFFA
Gene Alias: A330085O09Rik; DFF; DFF1; DFF35; Dff45; DFF-45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; RP23-121D17.3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1676
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide; pH 7.4
Gene Accession No.: O00273
Gene Symbols: DFFA
Immunogen: Peptide: amino acids 313-331 from the C-terminus of human DFF
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
ICAD
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
A330085O09Rik; DFF; DFF1; DFF35; Dff45; DFF-45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; RP23-121D17.3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1676
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide; pH 7.4
Gene Accession No.:
O00273
Gene Symbols:
DFFA
Immunogen:
Peptide: amino acids 313-331 from the C-terminus of human DFF
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: Caspase 3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CASP3
Gene Alias: A830040C14Rik; AC-3; Apopain; Apopain precursor; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase3; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; Caspase-3-like protein; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; cysteine protease; CPP32; apopain; ICE3; IRP; LICE; mLdy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Host Species: Rabbit
Purification Method: __
Regulatory Status: RUO
Gene ID (Entrez): 836
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: Conc. Not Determined
Formulation: whole serum with 0.09% sodium azide
Gene Accession No.: P42574
Gene Symbols: CASP3
Immunogen: Recombinant human caspase-3
Quantity: 50 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Caspase 3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CASP3
Gene Alias:
A830040C14Rik; AC-3; Apopain; Apopain precursor; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase3; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; Caspase-3-like protein; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; cysteine protease; CPP32; apopain; ICE3; IRP; LICE; mLdy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Host Species:
Rabbit
Purification Method:
__
Regulatory Status:
RUO
Gene ID (Entrez):
836
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
Conc. Not Determined
Formulation:
whole serum with 0.09% sodium azide
Gene Accession No.:
P42574
Gene Symbols:
CASP3
Immunogen:
Recombinant human caspase-3
Quantity:
50 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: GFR alpha-2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: GFRA2
Gene Alias: GDNF family receptor alpha 2; GDNF family receptor alpha-2; GDNF re; GDNF receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; Gdnfrb; GDNFR-beta; Gfra2; GFR-alpha 2; GFR-alpha-2; glial cell line derived neurotrophic factor family receptor alpha 2; glial cell line derived neurotrophic factor receptor, beta; HpV18gp1; neurturin receptor alpha; NRTNR-alpha; NTNRA; NTNR-alpha; PI-linked cell-surface accessory protein; RET ligand 2; RETL2; TGF-beta-related neurotrophic factor receptor 2; TRN receptor, GPI-anchored; TRNR2; tyrosine kinase receptor ligand 2
Host Species: Rabbit
Purification Method: Ion-exchange chromatography
Regulatory Status: RUO
Gene ID (Entrez): 14586, 25136, 2675
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: O00451, O08842
Gene Symbols: GFRA2
Immunogen: Synthetic peptide from C-terminus of human GFR alpha-2
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
GFR alpha-2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GFRA2
Gene Alias:
GDNF family receptor alpha 2; GDNF family receptor alpha-2; GDNF re; GDNF receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; Gdnfrb; GDNFR-beta; Gfra2; GFR-alpha 2; GFR-alpha-2; glial cell line derived neurotrophic factor family receptor alpha 2; glial cell line derived neurotrophic factor receptor, beta; HpV18gp1; neurturin receptor alpha; NRTNR-alpha; NTNRA; NTNR-alpha; PI-linked cell-surface accessory protein; RET ligand 2; RETL2; TGF-beta-related neurotrophic factor receptor 2; TRN receptor, GPI-anchored; TRNR2; tyrosine kinase receptor ligand 2
Host Species:
Rabbit
Purification Method:
Ion-exchange chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14586, 25136, 2675
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
O00451, O08842
Gene Symbols:
GFRA2
Immunogen:
Synthetic peptide from C-terminus of human GFR alpha-2
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: EDG3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: S1PR3
Gene Alias: AI132464; cardiac sphingosine-1-phosphate specific receptor; EDG3; EDG-3; Edg3l; Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; Lpb3; Lysophospholipid receptor B3; MGC71696; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; S1P receptor S1P3; S1p3; S1PR3; sphingosine; Sphingosine 1-phosphate receptor 3; sphingosine 1-phosphate receptor Edg-3; sphingosine-1-phosphate receptor 3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13610, 1903
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 0.1% sodium azide
Gene Accession No.: Q99500, Q9Z0U9
Gene Symbols: S1PR3
Immunogen: Synthetic 18 amino acid peptide from C-terminus of human EDG3 / S1P3.
Quantity: 25 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
EDG3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
S1PR3
Gene Alias:
AI132464; cardiac sphingosine-1-phosphate specific receptor; EDG3; EDG-3; Edg3l; Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; Lpb3; Lysophospholipid receptor B3; MGC71696; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; S1P receptor S1P3; S1p3; S1PR3; sphingosine; Sphingosine 1-phosphate receptor 3; sphingosine 1-phosphate receptor Edg-3; sphingosine-1-phosphate receptor 3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13610, 1903
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% sodium azide
Gene Accession No.:
Q99500, Q9Z0U9
Gene Symbols:
S1PR3
Immunogen:
Synthetic 18 amino acid peptide from C-terminus of human EDG3 / S1P3.
Quantity:
25 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG