Tramadol Polyclonal Antibody, Invitrogen™

Description

• PA1-75471 specifically detects Tramadol
• PA1-75471 has been successfully used in ELISA applications
• The PA1-75471 immunogen is Tramadol(N)-BTG
• Tramadol is only found in individuals that have used or taken this drug
• It is a narcotic analgesic proposed for moderate to severe pain
• It may be habituating
• [PubChem] Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists
• Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins
• As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase
• Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited
• The analgesic properties of Tramadol can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord
• The (+) enantiomer has higher affinity for the OP3 receptor and preferentially inhibits serotonin uptake and enhances serotonin release
• The (-) enantiomer preferentially inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors
• [National Center for Biotechnology Information
• PubChem Compound Database; CID=33741].