PIPA5100300
PHD3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5100300-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA5100300 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
PHD3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
EGLN3
Gene Alias
2610021G09Rik; AI505553; AI648162; Egl nine homolog 3; egl nine homolog 3, mitochondrial; egl nine-like protein 3 isoform; egl-9 family hypoxia inducible factor 3; egl-9 family hypoxia-inducible factor 3; EGLN3; factor-responsive smooth muscle protein; FLJ21620; HIF prolyl hydroxylase 3; HIFP4H3; Hif-p4h-3; HIFPH3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; MGC125998; MGC125999; P4H3; Phd3; PHD-3; prolyl hydroxylase domain-containing protein 3; Sm20; SM-20
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
112399, 112407
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q91UZ4, Q9H6Z9
Gene Symbols
EGLN3
Immunogen
A synthesized peptide derived from human EGLN3(Accession Q9H6Z9), corresponding to amino acid residues E37-G87.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total PHD3
- Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins
- Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A
- Also hydroxylates HIF2A
- Has a preference for the CODD site for both HIF1A and HIF2A
- Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site
- Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex
- Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes
- EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia
- Also hydroxylates PKM in hypoxia, limiting glycolysis
- Under normoxia, hydroxylates and regulates the stability of ADRB2
- Regulator of cardiomyocyte and neuronal apoptosis
- In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex
- In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity
- Also essential for hypoxic regulation of neutrophilic inflammation
- Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway
- Target proteins are preferentially recognized via a LXXLAP motif.
Compare Similar Items
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Antigen: PHD3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EGLN3
Gene Alias: 2610021G09Rik; AI505553; AI648162; Egl nine homolog 3; egl nine homolog 3, mitochondrial; egl nine-like protein 3 isoform; egl-9 family hypoxia inducible factor 3; egl-9 family hypoxia-inducible factor 3; EGLN3; factor-responsive smooth muscle protein; FLJ21620; HIF prolyl hydroxylase 3; HIFP4H3; Hif-p4h-3; HIFPH3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; MGC125998; MGC125999; P4H3; Phd3; PHD-3; prolyl hydroxylase domain-containing protein 3; Sm20; SM-20
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 112399, 112407
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q91UZ4, Q9H6Z9
Gene Symbols: EGLN3
Immunogen: A synthesized peptide derived from human EGLN3(Accession Q9H6Z9), corresponding to amino acid residues E37-G87.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
PHD3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EGLN3
Gene Alias:
2610021G09Rik; AI505553; AI648162; Egl nine homolog 3; egl nine homolog 3, mitochondrial; egl nine-like protein 3 isoform; egl-9 family hypoxia inducible factor 3; egl-9 family hypoxia-inducible factor 3; EGLN3; factor-responsive smooth muscle protein; FLJ21620; HIF prolyl hydroxylase 3; HIFP4H3; Hif-p4h-3; HIFPH3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; MGC125998; MGC125999; P4H3; Phd3; PHD-3; prolyl hydroxylase domain-containing protein 3; Sm20; SM-20
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
112399, 112407
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q91UZ4, Q9H6Z9
Gene Symbols:
EGLN3
Immunogen:
A synthesized peptide derived from human EGLN3(Accession Q9H6Z9), corresponding to amino acid residues E37-G87.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: PLEKHG5
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PLEKHG5
Gene Alias: BC023181; CMTRIC; DSMA4; GEF720; Guanine nucleotide exchange factor 720; Kiaa0720; Neuronal RhoA GEF protein; NFkB activating protein; novel PH domain-containing protein; PH domain-containing family G member 5; pleckstrin homology and RhoGEF domain containing G5; pleckstrin homology domain containing family G member 5; pleckstrin homology domain containing, family G (with RhoGef domain) member 5; pleckstrin homology domain-containing family G member 5; Plekhg5; RhoA-specific guanine exchange factor SYX1; RhoA-specific guanine exchange factor SYX2; synectin-binding guanine exchange factor; synectin-binding RhoA exchange factor; Syx; Tech; Transcript highly enriched in cortex and hippocampus
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 269608, 310999, 57449
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: O94827, Q66T02, Q6RFZ7
Gene Symbols: PLEKHG5
Immunogen: A synthesized peptide derived from human PLEKHG5(Accession O94827), corresponding to amino acid residues S844-E894.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
PLEKHG5
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PLEKHG5
Gene Alias:
BC023181; CMTRIC; DSMA4; GEF720; Guanine nucleotide exchange factor 720; Kiaa0720; Neuronal RhoA GEF protein; NFkB activating protein; novel PH domain-containing protein; PH domain-containing family G member 5; pleckstrin homology and RhoGEF domain containing G5; pleckstrin homology domain containing family G member 5; pleckstrin homology domain containing, family G (with RhoGef domain) member 5; pleckstrin homology domain-containing family G member 5; Plekhg5; RhoA-specific guanine exchange factor SYX1; RhoA-specific guanine exchange factor SYX2; synectin-binding guanine exchange factor; synectin-binding RhoA exchange factor; Syx; Tech; Transcript highly enriched in cortex and hippocampus
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
269608, 310999, 57449
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
O94827, Q66T02, Q6RFZ7
Gene Symbols:
PLEKHG5
Immunogen:
A synthesized peptide derived from human PLEKHG5(Accession O94827), corresponding to amino acid residues S844-E894.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: PPARGC1B
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Ppargc1b
Gene Alias: 4631412G21Rik; ERR ligand 1; ERRL1; Perc; peroxisome proliferative activated receptor gamma coactivator 1 beta; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC1; pgc-1 beta; PGC-1(beta); Pgc1b; PGC1beta; PGC-1beta; PGC-1-beta; PGC-1beta/ERRL1; PGC-1-related estrogen receptor alpha coactivator; PPAR gamma coactivator-1beta protein; PPARG coactivator 1 beta; PPARgamma coactivator 1 beta; PPAR-gamma coactivator 1-beta; PPARGC1; PPARGC1B; PPARGC-1-beta
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 133522, 170826
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q86YN6, Q8VHJ7
Gene Symbols: Ppargc1b
Immunogen: A synthesized peptide derived from human PPARGC1B(Accession Q86YN6), corresponding to amino acid residues H658-V708.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
PPARGC1B
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Ppargc1b
Gene Alias:
4631412G21Rik; ERR ligand 1; ERRL1; Perc; peroxisome proliferative activated receptor gamma coactivator 1 beta; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC1; pgc-1 beta; PGC-1(beta); Pgc1b; PGC1beta; PGC-1beta; PGC-1-beta; PGC-1beta/ERRL1; PGC-1-related estrogen receptor alpha coactivator; PPAR gamma coactivator-1beta protein; PPARG coactivator 1 beta; PPARgamma coactivator 1 beta; PPAR-gamma coactivator 1-beta; PPARGC1; PPARGC1B; PPARGC-1-beta
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
133522, 170826
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q86YN6, Q8VHJ7
Gene Symbols:
Ppargc1b
Immunogen:
A synthesized peptide derived from human PPARGC1B(Accession Q86YN6), corresponding to amino acid residues H658-V708.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: PRRT1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PRRT1
Gene Alias: Bat4; Bat-4; C6orf31; C7H6orf31; D17H6S54E; Dispanin subfamily D member 1; DSPD1; G5b; IFITMD7; interferon induced transmembrane protein domain containing 7; Ng5; Orf31; proline rich transmembrane protein 1; proline-rich transmembrane protein 1; PRRT1; prrt1 {ECO:0000250; Synapse differentiation-induced protein 4; SynDIG4; UniProtKB:Q99946}
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 260297, 406167, 80863
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: O35449, Q6MG82, Q99946
Gene Symbols: PRRT1
Immunogen: A synthesized peptide derived from human PRRT1(Accession Q99946), corresponding to amino acid residues M1-S39.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
PRRT1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PRRT1
Gene Alias:
Bat4; Bat-4; C6orf31; C7H6orf31; D17H6S54E; Dispanin subfamily D member 1; DSPD1; G5b; IFITMD7; interferon induced transmembrane protein domain containing 7; Ng5; Orf31; proline rich transmembrane protein 1; proline-rich transmembrane protein 1; PRRT1; prrt1 {ECO:0000250; Synapse differentiation-induced protein 4; SynDIG4; UniProtKB:Q99946}
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
260297, 406167, 80863
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
O35449, Q6MG82, Q99946
Gene Symbols:
PRRT1
Immunogen:
A synthesized peptide derived from human PRRT1(Accession Q99946), corresponding to amino acid residues M1-S39.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG