PIPA5104498
TIN2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104498-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA5104498 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
TIN2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Tinf2
Gene Alias
AW552114; D14Wsu146e; DKCA3; TERF1 (TRF1)-interacting nuclear factor 2; TERF1 interacting nuclear factor 2; TERF1-interacting nuclear factor 2; tin; TIN2; Tin-2; TINF2; TRF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
26277
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q9BSI4
Gene Symbols
Tinf2
Immunogen
A synthesized peptide derived from human TINF2(Accession Q9BSI4), corresponding to amino acid residues R74-A124.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Description
- Antibody detects endogenous levels of total TINF2
- TRF1 is a negative regulator of telomere length maintenance
- Recently two proteins, tankyrase and Tin2, which bind to mammalian TRF1, have been identified
- Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP)
- Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats
- Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP)-ribosylation
- Since ADP-ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, this suggests that telomere function in human cells is regulated by poly (ADP)-ribosylation
- Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase
- The cDNA coding for TIN2 protein was isolated as interacting partner of TRF1 from a yeast two-hybrid cDNA library screening
- Tin2 localizes to telomeres and is essential for proper regulation of telomere length
- TIN2, like TRF1, is widely and constitutively expressed, suggesting that these proteins act together to counterbalance telomere elongation by telomerase
- However, endogenous TIN2, like endogenousTRF1, is not highly expressed, and therefore may be difficult to visualize by immunostaining in certain cell systems.
Compare Similar Items
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Antigen: TIN2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Tinf2
Gene Alias: AW552114; D14Wsu146e; DKCA3; TERF1 (TRF1)-interacting nuclear factor 2; TERF1 interacting nuclear factor 2; TERF1-interacting nuclear factor 2; tin; TIN2; Tin-2; TINF2; TRF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 26277
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q9BSI4
Gene Symbols: Tinf2
Immunogen: A synthesized peptide derived from human TINF2(Accession Q9BSI4), corresponding to amino acid residues R74-A124.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
TIN2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Tinf2
Gene Alias:
AW552114; D14Wsu146e; DKCA3; TERF1 (TRF1)-interacting nuclear factor 2; TERF1 interacting nuclear factor 2; TERF1-interacting nuclear factor 2; tin; TIN2; Tin-2; TINF2; TRF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
26277
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q9BSI4
Gene Symbols:
Tinf2
Immunogen:
A synthesized peptide derived from human TINF2(Accession Q9BSI4), corresponding to amino acid residues R74-A124.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: DUS2L
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DUS2
Gene Alias: 2310016K04Rik; Dihydrouridine synthase 2; dihydrouridine synthase 2-like, SMM1 homolog; Dus2; Dus2l; hDUS2; RGD1305612; SMM1; SMM1 homolog; tRNA-dihydrouridine synthase 2-like; tRNA-dihydrouridine(20) synthase (NAD(P)(+)); tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Up-regulated in lung cancer protein 8; URLC8
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 291978, 54920, 66369
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q9D7B1, Q9NX74
Gene Symbols: DUS2
Immunogen: A synthesized peptide derived from human DUS2(Accession Q9NX74), corresponding to amino acid residues C430-V480.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
DUS2L
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DUS2
Gene Alias:
2310016K04Rik; Dihydrouridine synthase 2; dihydrouridine synthase 2-like, SMM1 homolog; Dus2; Dus2l; hDUS2; RGD1305612; SMM1; SMM1 homolog; tRNA-dihydrouridine synthase 2-like; tRNA-dihydrouridine(20) synthase (NAD(P)(+)); tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Up-regulated in lung cancer protein 8; URLC8
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
291978, 54920, 66369
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q9D7B1, Q9NX74
Gene Symbols:
DUS2
Immunogen:
A synthesized peptide derived from human DUS2(Accession Q9NX74), corresponding to amino acid residues C430-V480.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MEKK3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Map3k3
Gene Alias: AW548911; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; Mekk3; mitogen activated protein kinase kinase kinase 3; mitogen-activated protein kinase kinase kinase 3; mKIAA4031
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 26406, 4215
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q61084, Q99759
Gene Symbols: Map3k3
Immunogen: A synthesized peptide derived from human MAP3K3(Accession Q99759), corresponding to amino acid residues V76-N126.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
MEKK3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Map3k3
Gene Alias:
AW548911; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; Mekk3; mitogen activated protein kinase kinase kinase 3; mitogen-activated protein kinase kinase kinase 3; mKIAA4031
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
26406, 4215
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q61084, Q99759
Gene Symbols:
Map3k3
Immunogen:
A synthesized peptide derived from human MAP3K3(Accession Q99759), corresponding to amino acid residues V76-N126.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: YTHDF1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: YTHDF1
Gene Alias: 2210410K23Rik; 8030473O16; C20orf21; DACA-1; DACA-1 homolog; Dermatomyositis associated with cancer putative autoantigen 1; dermatomyositis associated with cancer putative autoantigen 1 homolog; fb49c02; wu:fb49c02; wu:fi19h06; wu:fj87f09; wu:fp06c11; YTH domain family 1; YTH domain family protein 1; YTH domain family, member 1; YTH domain-containing family protein 1; YTH N(6)-methyladenosine RNA binding protein 1; YTH N6-methyladenosine RNA binding protein 1; Ythdf1; zgc:55657
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 228994, 296467, 54915
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P59326, Q9BYJ9
Gene Symbols: YTHDF1
Immunogen: A synthesized peptide derived from human YTHDF1(Accession Q9BYJ9), corresponding to amino acid residues M1-Y37.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
YTHDF1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
YTHDF1
Gene Alias:
2210410K23Rik; 8030473O16; C20orf21; DACA-1; DACA-1 homolog; Dermatomyositis associated with cancer putative autoantigen 1; dermatomyositis associated with cancer putative autoantigen 1 homolog; fb49c02; wu:fb49c02; wu:fi19h06; wu:fj87f09; wu:fp06c11; YTH domain family 1; YTH domain family protein 1; YTH domain family, member 1; YTH domain-containing family protein 1; YTH N(6)-methyladenosine RNA binding protein 1; YTH N6-methyladenosine RNA binding protein 1; Ythdf1; zgc:55657
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
228994, 296467, 54915
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P59326, Q9BYJ9
Gene Symbols:
YTHDF1
Immunogen:
A synthesized peptide derived from human YTHDF1(Accession Q9BYJ9), corresponding to amino acid residues M1-Y37.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG