PIPA5104616
Phospho-MST1/MST2 (Thr183, Thr180) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104616-Each-of-1 | In Stock | ₹ 45,218.46 |
PIPA5104616 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,218.46
GST (18%): ₹ 8,139.323
Total Price: ₹ 53,357.783
Antigen
Phospho-MST1/MST2 (Thr183, Thr180)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
STK4
Gene Alias
0610042I06Rik; AI447339; AU020804; Kas-2; KB-1458E12.1; kinase responsive to stress 2; KRS1; KRS2; mammalian STE20-like protein kinase 1; Mammalian STE20-like protein kinase 2; mammalian sterile 20-like 1; mess1; MST; MST1; MST-1; MST1/C; MST1/C STK4; MST1/N; MST2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine kinase 4; serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4 37kDa subunit; Serine/threonine-protein kinase Krs-1; serine/threonine-protein kinase Krs-2; Ste20; STE20-like kinase MST1; STE20-like kinase MST2; sterile 20-like kinase 1; STK3; Stk4; Yeast Sps1/Ste20-related kinase 3; YSK3
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
311622, 56274, 58231, 65189, 6788, 6789
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O54748, Q13043, Q13188, Q9JI10, Q9JI11
Gene Symbols
Stk3, STK4
Immunogen
A synthesized peptide derived from human STK4(Accession Q13043), corresponding to amino acid residues around phosphorylated Thr183.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Description
- Antibody detectsAntibody detects endogenous levels of MST1 when phosphorylated at Thr183 or MST2 when phosphorylated at Thr180
- STK3 and STK4 are stress-activated, pro-apoptotic kinases which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation
- They are key components of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation
- Phosphorylates NKX2-1
- Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250
- In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation
- Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'
- Phosphorylates MOBKL1A and RASSF2
- Phosphorylates MOBKL1B on 'Thr-74'
- Acts cooperatively with MOBKL1B to activate STK38.
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Antigen: Phospho-MST1/MST2 (Thr183, Thr180)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: STK4
Gene Alias: 0610042I06Rik; AI447339; AU020804; Kas-2; KB-1458E12.1; kinase responsive to stress 2; KRS1; KRS2; mammalian STE20-like protein kinase 1; Mammalian STE20-like protein kinase 2; mammalian sterile 20-like 1; mess1; MST; MST1; MST-1; MST1/C; MST1/C STK4; MST1/N; MST2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine kinase 4; serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4 37kDa subunit; Serine/threonine-protein kinase Krs-1; serine/threonine-protein kinase Krs-2; Ste20; STE20-like kinase MST1; STE20-like kinase MST2; sterile 20-like kinase 1; STK3; Stk4; Yeast Sps1/Ste20-related kinase 3; YSK3
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 311622, 56274, 58231, 65189, 6788, 6789
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: O54748, Q13043, Q13188, Q9JI10, Q9JI11
Gene Symbols: Stk3, STK4
Immunogen: A synthesized peptide derived from human STK4(Accession Q13043), corresponding to amino acid residues around phosphorylated Thr183.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-MST1/MST2 (Thr183, Thr180)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
STK4
Gene Alias:
0610042I06Rik; AI447339; AU020804; Kas-2; KB-1458E12.1; kinase responsive to stress 2; KRS1; KRS2; mammalian STE20-like protein kinase 1; Mammalian STE20-like protein kinase 2; mammalian sterile 20-like 1; mess1; MST; MST1; MST-1; MST1/C; MST1/C STK4; MST1/N; MST2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine kinase 4; serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4 37kDa subunit; Serine/threonine-protein kinase Krs-1; serine/threonine-protein kinase Krs-2; Ste20; STE20-like kinase MST1; STE20-like kinase MST2; sterile 20-like kinase 1; STK3; Stk4; Yeast Sps1/Ste20-related kinase 3; YSK3
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
311622, 56274, 58231, 65189, 6788, 6789
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
O54748, Q13043, Q13188, Q9JI10, Q9JI11
Gene Symbols:
Stk3, STK4
Immunogen:
A synthesized peptide derived from human STK4(Accession Q13043), corresponding to amino acid residues around phosphorylated Thr183.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-MYPT1 (Thr696)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PPP1R12A
Gene Alias: 1200015F06Rik; 130 kDa myosin-binding subunit of smooth muscle myosin phophatase; 130 kDa myosin-binding subunit of smooth muscle myosin phophatase (M130); 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase; 130 kDa regulatory subunit of myosin phosphatase; 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133); 5730577I22Rik; AA792106; AV099298; D10Ertd625e; hypothetical protein; I79_016312; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12A; M110; M130; M130 of smooth muscle myosin phosphatase; MBS; MBSP; myosin binding subunit; myosin phosphatase target subunit 1; myosin phosphatase, target subunit 1; myosin phosphatase-targeting subunit 1; myosin-binding subunit of myosin phosphatase; Mypt1; PP-1M; PP1M M110 subunit; PP1M subunit M110; Ppp1r12a; Protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase 1, regulatory subunit 12A; protein phosphatase 1M 110 kda regulato
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 116670, 17931, 4659
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: O14974, Q10728, Q9DBR7
Gene Symbols: PPP1R12A
Immunogen: A synthesized peptide derived from human PPP1R12A(Accession O14974), corresponding to amino acid residues around phosphorylated Thr696.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-MYPT1 (Thr696)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PPP1R12A
Gene Alias:
1200015F06Rik; 130 kDa myosin-binding subunit of smooth muscle myosin phophatase; 130 kDa myosin-binding subunit of smooth muscle myosin phophatase (M130); 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase; 130 kDa regulatory subunit of myosin phosphatase; 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133); 5730577I22Rik; AA792106; AV099298; D10Ertd625e; hypothetical protein; I79_016312; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12A; M110; M130; M130 of smooth muscle myosin phosphatase; MBS; MBSP; myosin binding subunit; myosin phosphatase target subunit 1; myosin phosphatase, target subunit 1; myosin phosphatase-targeting subunit 1; myosin-binding subunit of myosin phosphatase; Mypt1; PP-1M; PP1M M110 subunit; PP1M subunit M110; Ppp1r12a; Protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase 1, regulatory subunit 12A; protein phosphatase 1M 110 kda regulato
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
116670, 17931, 4659
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
O14974, Q10728, Q9DBR7
Gene Symbols:
PPP1R12A
Immunogen:
A synthesized peptide derived from human PPP1R12A(Accession O14974), corresponding to amino acid residues around phosphorylated Thr696.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-PKMYT1 (Ser83)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Pkmyt1
Gene Alias: 6230424P17; AW209059; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase; Myt1; Myt1 kinase; Pkmyt1; pkmyt1.S; PPP1R126; protein kinase, membrane associated tyrosine/threonine 1; protein kinase, membrane associated tyrosine/threonine 1 S homeolog; protein phosphatase 1, regulatory subunit 126; RGD1305434; XELAEV_18047881mg
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9088
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q99640
Gene Symbols: Pkmyt1
Immunogen: A synthesized peptide derived from human PKMYT1(Accession Q99640), corresponding to amino acid residues around phosphorylated Ser83.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-PKMYT1 (Ser83)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Pkmyt1
Gene Alias:
6230424P17; AW209059; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase; Myt1; Myt1 kinase; Pkmyt1; pkmyt1.S; PPP1R126; protein kinase, membrane associated tyrosine/threonine 1; protein kinase, membrane associated tyrosine/threonine 1 S homeolog; protein phosphatase 1, regulatory subunit 126; RGD1305434; XELAEV_18047881mg
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9088
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q99640
Gene Symbols:
Pkmyt1
Immunogen:
A synthesized peptide derived from human PKMYT1(Accession Q99640), corresponding to amino acid residues around phosphorylated Ser83.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-NMDAR2B (Ser1284)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: GRIN2B
Gene Alias: AW490526; EIEE27; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; GRIN2B; HGNC:4586; hNR 3; hNR3; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B; MGC142178; MGC142180; MRD6; Nmdar2b; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 14812, 24410, 2904
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q00960, Q01097, Q13224
Gene Symbols: GRIN2B
Immunogen: A synthesized peptide derived from human GRIN2B(Accession Q13224), corresponding to amino acid residues around phosphorylated Ser1284.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-NMDAR2B (Ser1284)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GRIN2B
Gene Alias:
AW490526; EIEE27; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; GRIN2B; HGNC:4586; hNR 3; hNR3; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B; MGC142178; MGC142180; MRD6; Nmdar2b; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14812, 24410, 2904
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q00960, Q01097, Q13224
Gene Symbols:
GRIN2B
Immunogen:
A synthesized peptide derived from human GRIN2B(Accession Q13224), corresponding to amino acid residues around phosphorylated Ser1284.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG