PIPA5104694

Phospho-IKK beta (Tyr199) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PIPA5104694-Each-of-1 In Stock ₹ 45,218.46

PIPA5104694 - Each of 1

₹ 45,218.46

In Stock

Quantity

1

Base Price: ₹ 45,218.46

GST (18%): ₹ 8,139.323

Total Price: ₹ 53,357.783

Antigen

Phospho-IKK beta (Tyr199)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

Ikbkb

Gene Alias

AI132552; AIM-1; FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; Ikbkb; IKK[b]; IKK2; IKK-2; IKKB; IKK-B; IKKbeta; IKK-beta; IMD15; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta

Host Species

Rabbit

Purification Method

sequential chromatography

Regulatory Status

RUO

Gene ID (Entrez)

16150, 3551, 84351

Content And Storage

-20°C

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.

O14920, O88351, Q9QY78

Gene Symbols

Ikbkb

Immunogen

A synthesized peptide derived from human IKBKB(Accession O14920), corresponding to amino acid residues around phosphorylated Tyr199.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Non-human Primate, Rat

Product Type

Antibody

Isotype

IgG

Description

  • Antibody detects endogenous levels of IKK beta only when phosphorylated at Tyrosine 199
  • Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex
  • Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses
  • IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues
  • These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome
  • In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis
  • Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).

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Thermo Scientific

PIPA5104694

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Antigen:
Phospho-IKK beta (Tyr199)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Ikbkb

Gene Alias:
AI132552; AIM-1; FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; Ikbkb; IKK[b]; IKK2; IKK-2; IKKB; IKK-B; IKKbeta; IKK-beta; IMD15; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
16150, 3551, 84351

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
O14920, O88351, Q9QY78

Gene Symbols:
Ikbkb

Immunogen:
A synthesized peptide derived from human IKBKB(Accession O14920), corresponding to amino acid residues around phosphorylated Tyr199.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Non-human Primate, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5104696

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Antigen:
Phospho-IKK alpha/beta (Ser180, Ser181)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
CHUK

Gene Alias:
AI132552; AI256658; AIM-1; CHUK; Chuk1; component of inhibitor of nuclear factor kappa B kinase complex; conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; Fbx24; Fbxo24; I kappa B kinase 1; i kappa-B kinase alpha; IkappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase 2; IkappaB kinase alpha; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; I-kappa-B-kinase beta; IkB kinase alpha subunit; IkB kinase-alpha; IkB kinase-beta; ikBKA; Ikbkb; IKK alpha; IKK[b]; IKK1; IKK2; IKK-2; IKKA; IKK-A; IKK-a kinase; IKK-alpha; Ikkb; IKK-B; IKKbeta; IKK-beta; IMD15; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; inhibitor of nuclear factor kappa B kinase subunit beta; inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; Nuclear factor NFkappaB inhibitor kinase alpha; nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; TCF16; TCF-16; TCF17; Transcription factor 16

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
1147, 12675, 16150, 309361, 3551, 84351

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
O14920, O15111, O88351, Q60680, Q9QY78

Gene Symbols:
CHUK, Ikbkb

Immunogen:
A synthesized peptide derived from human CHUK(Accession O15111), corresponding to amino acid residues around phosphorylated Ser180.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5104697

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Antigen:
Phospho-IKK alpha/beta (Ser176, Ser177)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Ikbkb

Gene Alias:
AI132552; AI256658; AIM-1; CHUK; Chuk1; component of inhibitor of nuclear factor kappa B kinase complex; conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; Fbx24; Fbxo24; I kappa B kinase 1; i kappa-B kinase alpha; IkappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase 2; IkappaB kinase alpha; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; I-kappa-B-kinase beta; IkB kinase alpha subunit; IkB kinase-alpha; IkB kinase-beta; ikBKA; Ikbkb; IKK alpha; IKK[b]; IKK1; IKK2; IKK-2; IKKA; IKK-A; IKK-a kinase; IKK-alpha; Ikkb; IKK-B; IKKbeta; IKK-beta; IMD15; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; inhibitor of nuclear factor kappa B kinase subunit beta; inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; Nuclear factor NFkappaB inhibitor kinase alpha; nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; TCF16; TCF-16; TCF17; Transcription factor 16

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
1147, 12675, 16150, 309361, 3551, 84351

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
O14920, O15111, O88351, Q60680, Q9QY78

Gene Symbols:
CHUK, Ikbkb

Immunogen:
A synthesized peptide derived from human CHUK(Accession O15111), corresponding to amino acid residues around phosphorylated Ser176.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5104699

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Antigen:
Phospho-Survivin (Thr117)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Birc5

Gene Alias:
AAC-11; AP14; Api4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; EPR-1; Iap4; inhibitor of apoptosis; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
11799, 332, 64041

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
O15392, O70201, Q9JHY7

Gene Symbols:
Birc5

Immunogen:
A synthesized peptide derived from human BIRC5(Accession O15392), corresponding to amino acid residues around phosphorylated Thr117.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG