PIPA5105245
Phospho-ATF6 (Thr166) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105245-Each-of-1 | In Stock | ₹ 43,592.82 |
PIPA5105245 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,592.82
GST (18%): ₹ 7,846.708
Total Price: ₹ 51,439.528
Antigen
Phospho-ATF6 (Thr166)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ATF6
Gene Alias
9130025P16Rik; 9630036G24; AA617266; AA789574; ACHM7; activating transcription factor 6; activating transcription factor 6 alpha; Activating transcription factor 6 beta; ATF 6; Atf6; ATF6 alpha; ATF6A; Atf6alpha; ATF6-alpha; Atf6b; ATF6beta; ATF6-beta; cAMP response element binding protein-related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; Crebl1; Creb-related protein; CREB-RP; Cyclic AMP-dependent transcription factor ATF-6 alpha; cyclic AMP-dependent transcription factor ATF-6 beta; DKFZp686P2194; ESTM49; FLJ21663; G13; Processed cyclic AMP-dependent transcription factor ATF-6 alpha; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12915, 1388, 226641, 22926, 304962, 406169
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
F6VAN0, G3V909, O35451, P18850, Q99941
Gene Symbols
ATF6, ATF6B
Immunogen
A synthesized peptide derived from human ATF6(Accession P18850), corresponding to amino acid residues around phosphorylated Thr166.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of ATF6 only when phosphorylated at Thr166
- ATF6 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes
- It binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3')
- Binding to ERSE requires binding of NF-Y to ERSE
- ATF6 could also be involved in activation of transcription by the serum response factor
- ATF6 exists as a homodimer and heterodimer with ATF6 beta
- The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC)
- It Interacts also with the transcription factors GTF2I, YY1 and SRF
- Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus
- The basic domain of ATF6 functions as a nuclear localization signal and the basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE
- During the unfolded protein response an approximately 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis
- The cleavage seems to be performed sequentially by site-1 and site-2 proteases
- ATF6 is N-glycosylated, phosphorylated in vitro by MAPK14/P38MAPK and belongs to the bZIP family.
Compare Similar Items
Show Difference
Antigen: Phospho-ATF6 (Thr166)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ATF6
Gene Alias: 9130025P16Rik; 9630036G24; AA617266; AA789574; ACHM7; activating transcription factor 6; activating transcription factor 6 alpha; Activating transcription factor 6 beta; ATF 6; Atf6; ATF6 alpha; ATF6A; Atf6alpha; ATF6-alpha; Atf6b; ATF6beta; ATF6-beta; cAMP response element binding protein-related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; Crebl1; Creb-related protein; CREB-RP; Cyclic AMP-dependent transcription factor ATF-6 alpha; cyclic AMP-dependent transcription factor ATF-6 beta; DKFZp686P2194; ESTM49; FLJ21663; G13; Processed cyclic AMP-dependent transcription factor ATF-6 alpha; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12915, 1388, 226641, 22926, 304962, 406169
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: F6VAN0, G3V909, O35451, P18850, Q99941
Gene Symbols: ATF6, ATF6B
Immunogen: A synthesized peptide derived from human ATF6(Accession P18850), corresponding to amino acid residues around phosphorylated Thr166.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-ATF6 (Thr166)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ATF6
Gene Alias:
9130025P16Rik; 9630036G24; AA617266; AA789574; ACHM7; activating transcription factor 6; activating transcription factor 6 alpha; Activating transcription factor 6 beta; ATF 6; Atf6; ATF6 alpha; ATF6A; Atf6alpha; ATF6-alpha; Atf6b; ATF6beta; ATF6-beta; cAMP response element binding protein-related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; Crebl1; Creb-related protein; CREB-RP; Cyclic AMP-dependent transcription factor ATF-6 alpha; cyclic AMP-dependent transcription factor ATF-6 beta; DKFZp686P2194; ESTM49; FLJ21663; G13; Processed cyclic AMP-dependent transcription factor ATF-6 alpha; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12915, 1388, 226641, 22926, 304962, 406169
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
F6VAN0, G3V909, O35451, P18850, Q99941
Gene Symbols:
ATF6, ATF6B
Immunogen:
A synthesized peptide derived from human ATF6(Accession P18850), corresponding to amino acid residues around phosphorylated Thr166.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-RIP3 (Ser316)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RIPK3
Gene Alias: 2610528K09Rik; AW107945; Hcyp2; Homocysteine respondent protein HCYP2; mRIP3; receptor interacting protein 3; receptor interacting serine/threonine kinase 3; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine-threonine kinase 3; Rip3; RIP-3; Ripk3; RIP-like protein kinase 3
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11035
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q9Y572
Gene Symbols: RIPK3
Immunogen: A synthesized peptide derived from human RIPK3(Accession Q9Y572), corresponding to amino acid residues around phosphorylated Ser316.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-RIP3 (Ser316)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RIPK3
Gene Alias:
2610528K09Rik; AW107945; Hcyp2; Homocysteine respondent protein HCYP2; mRIP3; receptor interacting protein 3; receptor interacting serine/threonine kinase 3; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine-threonine kinase 3; Rip3; RIP-3; Ripk3; RIP-like protein kinase 3
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11035
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q9Y572
Gene Symbols:
RIPK3
Immunogen:
A synthesized peptide derived from human RIPK3(Accession Q9Y572), corresponding to amino acid residues around phosphorylated Ser316.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: RyR3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RYR3
Gene Alias: AI851294; Brain ryanodine receptor-calcium release channel; brain-type ryanodine receptor; C230090H21; calcium release channel; HBRR; Ryanodine receptor 3; RYR3; RYR-3; Type 3 ryanodine receptor
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20192, 6263
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: A2AGL3, Q15413
Gene Symbols: RYR3
Immunogen: A synthesized peptide derived from human RYR3(Accession Q15413), corresponding to amino acid residues A134-L184.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
RyR3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RYR3
Gene Alias:
AI851294; Brain ryanodine receptor-calcium release channel; brain-type ryanodine receptor; C230090H21; calcium release channel; HBRR; Ryanodine receptor 3; RYR3; RYR-3; Type 3 ryanodine receptor
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20192, 6263
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
A2AGL3, Q15413
Gene Symbols:
RYR3
Immunogen:
A synthesized peptide derived from human RYR3(Accession Q15413), corresponding to amino acid residues A134-L184.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: 53BP2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TP53BP2
Gene Alias: 53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; ASPP2; BBP; Bcl2-binding protein; P PPP1R13A; P53BP2; PPP1R13A; Renal carcinoma antigen NY-REN-51; TP53BP2; transformation related protein 53 binding protein 2; Trp53bp2; tumor protein p53 binding protein 2; tumor protein p53 binding protein, 2; tumor suppressor p53-binding protein 2
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 305025, 7159
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q13625
Gene Symbols: TP53BP2
Immunogen: A synthesized peptide derived from human TP53BP2(Accession Q13625), corresponding to amino acid residues G672-R722.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
53BP2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TP53BP2
Gene Alias:
53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; ASPP2; BBP; Bcl2-binding protein; P PPP1R13A; P53BP2; PPP1R13A; Renal carcinoma antigen NY-REN-51; TP53BP2; transformation related protein 53 binding protein 2; Trp53bp2; tumor protein p53 binding protein 2; tumor protein p53 binding protein, 2; tumor suppressor p53-binding protein 2
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
305025, 7159
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q13625
Gene Symbols:
TP53BP2
Immunogen:
A synthesized peptide derived from human TP53BP2(Accession Q13625), corresponding to amino acid residues G672-R722.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG