PIPA5105747
Phospho-BACE1 (Ser498) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105747-Each-of-1 | In Stock | ₹ 43,592.82 |
PIPA5105747 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,592.82
GST (18%): ₹ 7,846.708
Total Price: ₹ 51,439.528
Antigen
Phospho-BACE1 (Ser498)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BACE1
Gene Alias
APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; C76936; HSPC104; hypothetical protein LOC403005; KIAA1149; Memapsin; Memapsin2; Memapsin-2; membrane-associated aspartic protease 2; protease; transmembrane aspartic proteinase Asp2; zgc:77409
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23621, 23821, 29392
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P56817, P56818, P56819
Gene Symbols
BACE1
Immunogen
A synthesized peptide derived from human BACE1(Accession P56817), corresponding to amino acid residues around phosphorylated Ser498.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of BACE only when phosphorylated at Ser498
- BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer's disease (AD)
- In some cases early onset familial AD can be attributed to a "Swedish" mutation in the amyloid precursor protein (APP), which dramatically enhances the cleavage of this protein by BACE1
- This and other genetic and pathological evidence has led to therapeutic approaches that have focused on the inhibition of BACE1 and other APP-cleaving enzymes, such as gamma-secretase stuff
- APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99)
- The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease
- The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)
- bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Compare Similar Items
Show Difference
Antigen: Phospho-BACE1 (Ser498)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: BACE1
Gene Alias: APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; C76936; HSPC104; hypothetical protein LOC403005; KIAA1149; Memapsin; Memapsin2; Memapsin-2; membrane-associated aspartic protease 2; protease; transmembrane aspartic proteinase Asp2; zgc:77409
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23621, 23821, 29392
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P56817, P56818, P56819
Gene Symbols: BACE1
Immunogen: A synthesized peptide derived from human BACE1(Accession P56817), corresponding to amino acid residues around phosphorylated Ser498.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-BACE1 (Ser498)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
BACE1
Gene Alias:
APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; C76936; HSPC104; hypothetical protein LOC403005; KIAA1149; Memapsin; Memapsin2; Memapsin-2; membrane-associated aspartic protease 2; protease; transmembrane aspartic proteinase Asp2; zgc:77409
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23621, 23821, 29392
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P56817, P56818, P56819
Gene Symbols:
BACE1
Immunogen:
A synthesized peptide derived from human BACE1(Accession P56817), corresponding to amino acid residues around phosphorylated Ser498.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-INSR (Tyr999)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: INSR
Gene Alias: 4932439J01Rik; CD 220; CD220; CD220 antigen; CD220 beta; CD221; D630014A15Rik; HHF 5; HHF5; IGF-I receptor; INSR; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR1; IR-1; IR-A; IR-B
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16337, 24954, 3643
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P06213, P15127, P15208
Gene Symbols: INSR
Immunogen: A synthesized peptide derived from human INSR(Accession P06213), corresponding to amino acid residues around phosphorylated Tyr999.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-INSR (Tyr999)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
INSR
Gene Alias:
4932439J01Rik; CD 220; CD220; CD220 antigen; CD220 beta; CD221; D630014A15Rik; HHF 5; HHF5; IGF-I receptor; INSR; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR1; IR-1; IR-A; IR-B
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16337, 24954, 3643
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P06213, P15127, P15208
Gene Symbols:
INSR
Immunogen:
A synthesized peptide derived from human INSR(Accession P06213), corresponding to amino acid residues around phosphorylated Tyr999.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-IRAK1 (Thr387)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Irak1
Gene Alias: AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16179, 363520, 3654
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P51617, Q62406
Gene Symbols: Irak1
Immunogen: A synthesized peptide derived from human IRAK1(Accession P51617), corresponding to amino acid residues around phosphorylated Thr387.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-IRAK1 (Thr387)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Irak1
Gene Alias:
AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16179, 363520, 3654
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P51617, Q62406
Gene Symbols:
Irak1
Immunogen:
A synthesized peptide derived from human IRAK1(Accession P51617), corresponding to amino acid residues around phosphorylated Thr387.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-MYL9 (Thr19, Ser20)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MYL9
Gene Alias: 20 kDa myosin light chain; AI327049; DTNB; G1; Isoform L20-A; LC20; light polypeptide 9; MGC3505; MLC2; MLC-2; MLC20; MLC-2C; MRLC1; myl9; myl9.L; myl9b; myl9l; Mylc2c; myosin light chain 2; myosin light chain 9; myosin light chain 9 L homeolog; myosin light chain, regulatory C; myosin regulatory light chain; myosin regulatory light chain 1; myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 2, smooth muscle major isoform; myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; myosin regulatory light polypeptide 9; myosin regulatory light polypeptide 9b; myosin RLC; myosin, light chain 9, regulatory; myosin, light chain 9b, regulatory; myosin, light polypeptide 9, regulatory; Myrl2; RLC-C; smooth muscle major isoform; unnamed protein product; XELAEV_18003093mg; zgc:77916
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10398, 296313, 98932
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P24844, Q64122, Q9CQ19
Gene Symbols: MYL9
Immunogen: A synthesized peptide derived from human MYL9(Accession P24844), corresponding to amino acid residues around phosphorylated Ser20.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-MYL9 (Thr19, Ser20)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MYL9
Gene Alias:
20 kDa myosin light chain; AI327049; DTNB; G1; Isoform L20-A; LC20; light polypeptide 9; MGC3505; MLC2; MLC-2; MLC20; MLC-2C; MRLC1; myl9; myl9.L; myl9b; myl9l; Mylc2c; myosin light chain 2; myosin light chain 9; myosin light chain 9 L homeolog; myosin light chain, regulatory C; myosin regulatory light chain; myosin regulatory light chain 1; myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 2, smooth muscle major isoform; myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; myosin regulatory light polypeptide 9; myosin regulatory light polypeptide 9b; myosin RLC; myosin, light chain 9, regulatory; myosin, light chain 9b, regulatory; myosin, light polypeptide 9, regulatory; Myrl2; RLC-C; smooth muscle major isoform; unnamed protein product; XELAEV_18003093mg; zgc:77916
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10398, 296313, 98932
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P24844, Q64122, Q9CQ19
Gene Symbols:
MYL9
Immunogen:
A synthesized peptide derived from human MYL9(Accession P24844), corresponding to amino acid residues around phosphorylated Ser20.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG