PIPA5106117

Phospho-ATM (Ser794) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PIPA5106117-Each-of-1 In Stock ₹ 44,705.10

PIPA5106117 - Each of 1

₹ 44,705.10

In Stock

Quantity

1

Base Price: ₹ 44,705.10

GST (18%): ₹ 8,046.918

Total Price: ₹ 52,752.018

Antigen

Phospho-ATM (Ser794)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

ATM

Gene Alias

AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1

Host Species

Rabbit

Purification Method

sequential chromatography

Regulatory Status

RUO

Gene ID (Entrez)

472

Content And Storage

-20°C

Form

Liquid

Applications

Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.

Q13315

Gene Symbols

ATM

Immunogen

A synthesized peptide derived from human ATM(Accession Q13315), corresponding to amino acid residues around phosphorylated Ser794.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • Antibody detects endogenous levels of ATM only when phosphorylated at Ser794
  • Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family
  • Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer
  • The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily
  • ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1
  • The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens
  • The ATM’s C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases)
  • Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation
  • AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction
  • Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair
  • Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

Compare Similar Items

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Thermo Scientific

PIPA5106117

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Antigen:
Phospho-ATM (Ser794)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ATM

Gene Alias:
AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
472

Content And Storage:
-20°C

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
Q13315

Gene Symbols:
ATM

Immunogen:
A synthesized peptide derived from human ATM(Accession Q13315), corresponding to amino acid residues around phosphorylated Ser794.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

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PIPA5106119

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Antigen:
Phospho-CEACAM1 (Ser508)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
CEACAM1

Gene Alias:
antigen CD66; ATP-dependent taurocolate-carrier protein; bb-1; BGP; BGP1; BGP-1; BGPI; BGPR; Biliary glycoprotein 1; biliary glycoprotein D; bone gamma-carboxyglutamic acid (Gla) protein; carcinoembryonic antigen 1; carcinoembryonic antigen 7; carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Cc1; C-CAM; C-CAM 105; Ccam1; CD66a; CD66a antigen; Cea1; Cea-1; Cea7; Cea-7; CEACAM1; CEA-related cell adhesion molecule 1; CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin); Cell-CAM 105; ecto-ATPase; GP110; hepatitis virus (MHV-4) susceptibility; hepatitis virus receptor; Hv2; Hv-2; mCEA1; Mhv-1; MHVR; MHV-R; MHVR1; mmCGM1; mmCGM1a; mmCGM2; murine hepatitis virus receptor; osteocalcin; pp120; pp120/ecto-ATPase

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
634, 81613

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P13688, P16573

Gene Symbols:
CEACAM1

Immunogen:
A synthesized peptide derived from human CEACAM1(Accession P13688), corresponding to amino acid residues around phosphorylated Ser508.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Rat

Product Type:
Antibody

Isotype:
IgG

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PIPA5106121

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Antigen:
Phospho-DRP1 (Thr509)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
CRMP1

Gene Alias:
6330417M19Rik; AI450666; C-terminal region; Dlp1; dnm1l; Dnm1p/Vps1p-like protein; Dnml1; Dnmlp1; Drp1; DVLP; DYMPLE; dynamin 1 like; dynamin 1-like; dynamin family member proline-rich carboxyl-terminal domain less; Dynamin-1-like protein; Dynamin-1-like protein-like protein; Dynamin-like protein; dynamin-like protein 1; dynamin-like protein 4; Dynamin-like protein IV; dynamin-related protein 1; DYNIV 11; DYNIV-11; EC 3.6.5.5; EGK_03514; EMPF; FLJ41912; HDYNIV; N-terminal region; python; similar to dynamin 1-like; VPS1; zgc:66163

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
12933, 1400, 25415

Content And Storage:
-20°C

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P97427, Q14194, Q62950

Gene Symbols:
CRMP1

Immunogen:
A synthesized peptide derived from human CRMP1(Accession Q14194), corresponding to amino acid residues around phosphorylated Thr509.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

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PIPA5106122

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Antigen:
Phospho-CSF1R (Tyr921)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Csf1r

Gene Alias:
AI323359; CD115; CD115 antigen; C-FMS; colony stimulating factor 1 receptor; colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1 receptor; CSF1R; CSF-1R; CSF-1-R; CSFIR; Csfmr; CSFR; EC 2.7.10.1; FIM2; Fim-2; FMS; fms proto-oncogene; HDLS; kinase CSFR; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; M-CSFR; M-CSF-R; mrfms; OTTHUMP00000224093; protein-tyrosine kinase; proto-oncogene c-Fms; proto-oncogene fms

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
12978, 1436, 307403

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P07333, P09581, Q00495

Gene Symbols:
Csf1r

Immunogen:
A synthesized peptide derived from rat CSF1R(Accession P07333), corresponding to amino acid residues around phosphorylated Tyr921.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG