PIPA5106254
SIK1/SIK2/SIK3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5106254-Each-of-1 | In Stock | ₹ 40,127.64 |
PIPA5106254 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,127.64
GST (18%): ₹ 7,222.975
Total Price: ₹ 47,350.615
Antigen
SIK1/SIK2/SIK3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SIK1
Gene Alias
QIK, QSK
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
150094, 17691, 23235, 23387, 235344, 315649, 59329, 684112, 70661
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P57059, Q60670, Q6P4S6, Q8CFH6, Q9H0K1, Q9R1U5, Q9Y2K2
Gene Symbols
SIK1, SIK2, SIK3
Immunogen
A synthesized peptide derived from human SIK1(Accession P57059), corresponding to amino acid residues K164-L214.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total QIK/QSK
- Serine/threonine-protein kinase (SIK1) involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression
- Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1
- Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling
- Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis
- Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1
- Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes
- Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2
- Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity
- Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1
- In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1
- SIK2 phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction
- Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators
- SIK3 is a positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor
- Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis
- Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable)
- Prevents HDAC4 translocation to the nucleus.
Compare Similar Items
Show Difference
Antigen: SIK1/SIK2/SIK3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SIK1
Gene Alias: QIK, QSK
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 150094, 17691, 23235, 23387, 235344, 315649, 59329, 684112, 70661
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P57059, Q60670, Q6P4S6, Q8CFH6, Q9H0K1, Q9R1U5, Q9Y2K2
Gene Symbols: SIK1, SIK2, SIK3
Immunogen: A synthesized peptide derived from human SIK1(Accession P57059), corresponding to amino acid residues K164-L214.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SIK1/SIK2/SIK3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SIK1
Gene Alias:
QIK, QSK
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
150094, 17691, 23235, 23387, 235344, 315649, 59329, 684112, 70661
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P57059, Q60670, Q6P4S6, Q8CFH6, Q9H0K1, Q9R1U5, Q9Y2K2
Gene Symbols:
SIK1, SIK2, SIK3
Immunogen:
A synthesized peptide derived from human SIK1(Accession P57059), corresponding to amino acid residues K164-L214.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: ROS1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ROS1
Gene Alias: c-ros; c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; MCF3; Proto-oncogene c-Ros; proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; receptor tyrosine kinase c-ros oncogene 1; ROS; ROS proto-oncogene 1 , receptor tyrosine kinase; ROS proto-oncogene 1, receptor tyrosine kinase; Ros1; Ros-1; Ros1 proto-oncogene; ROS1C; RP1-179P9.1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 25346, 6098
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P08922, Q63132
Gene Symbols: ROS1
Immunogen: A synthesized peptide derived from human ROS1(Accession P08922), corresponding to amino acid residues D2249-S2299.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
ROS1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ROS1
Gene Alias:
c-ros; c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; MCF3; Proto-oncogene c-Ros; proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; receptor tyrosine kinase c-ros oncogene 1; ROS; ROS proto-oncogene 1 , receptor tyrosine kinase; ROS proto-oncogene 1, receptor tyrosine kinase; Ros1; Ros-1; Ros1 proto-oncogene; ROS1C; RP1-179P9.1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
25346, 6098
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P08922, Q63132
Gene Symbols:
ROS1
Immunogen:
A synthesized peptide derived from human ROS1(Accession P08922), corresponding to amino acid residues D2249-S2299.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: EphB1/EphB3/EphB4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EPHB4
Gene Alias: 9330129L11; AI042935; AW456895; AW488255; C130099E04Rik; Cek10; Cek6; Developmental kinase 2; developmental kinase 5; EK2; EK6; Elk; Elkh; ELK-related protein tyrosine kinase; Embryonic kinase 2; ENSMUSG00000074119; EPH receptor B1; Eph receptor B2 (ELK-related protein tyrosine kinase); Eph receptor B3; Eph receptor B4; eph tyrosine kinase 2; Ephb1; Ephb2; EPHB3; Ephb4; EPH-like kinase 2; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; ephrin receptor EphB4; ephrin type-B receptor 1; Ephrin type-B receptor 3; ephrin type-B receptor 4; EPHT2; Epth2; Erk; ETK2; HEK2; Hek6; Hepatoma transmembrane kinase; HTK; human embryo kinase 2; MDK2; mDK-2; Mdk5; mDK-5; Myk1; NET; Neuronally-expressed EPH-related tyrosine kinase; Sek4; soluble EPHB1 variant 1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyro11; TYRO6; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor EPH-2; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase rec
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13845, 13846, 2047, 2049, 2050, 24338, 270190, 287989, 686310
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P09759, P54753, P54754, P54760, P54761, P54762, Q8CBF3
Gene Symbols: EPHB1, EPHB3, EPHB4
Immunogen: A synthesized peptide derived from human EPHB1(Accession P54762), corresponding to amino acid residues N755-S805.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
EphB1/EphB3/EphB4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EPHB4
Gene Alias:
9330129L11; AI042935; AW456895; AW488255; C130099E04Rik; Cek10; Cek6; Developmental kinase 2; developmental kinase 5; EK2; EK6; Elk; Elkh; ELK-related protein tyrosine kinase; Embryonic kinase 2; ENSMUSG00000074119; EPH receptor B1; Eph receptor B2 (ELK-related protein tyrosine kinase); Eph receptor B3; Eph receptor B4; eph tyrosine kinase 2; Ephb1; Ephb2; EPHB3; Ephb4; EPH-like kinase 2; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; ephrin receptor EphB4; ephrin type-B receptor 1; Ephrin type-B receptor 3; ephrin type-B receptor 4; EPHT2; Epth2; Erk; ETK2; HEK2; Hek6; Hepatoma transmembrane kinase; HTK; human embryo kinase 2; MDK2; mDK-2; Mdk5; mDK-5; Myk1; NET; Neuronally-expressed EPH-related tyrosine kinase; Sek4; soluble EPHB1 variant 1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyro11; TYRO6; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor EPH-2; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase rec
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13845, 13846, 2047, 2049, 2050, 24338, 270190, 287989, 686310
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P09759, P54753, P54754, P54760, P54761, P54762, Q8CBF3
Gene Symbols:
EPHB1, EPHB3, EPHB4
Immunogen:
A synthesized peptide derived from human EPHB1(Accession P54762), corresponding to amino acid residues N755-S805.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CtBP1/CtBP2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CTBP2
Gene Alias: 50 kDa BFA-dependent ADP-ribosylation substrate; 50-kDa BFA-induced ADP-ribosylated substrate; 50-kDaBFA-inducedADP-ribosylatedsubstrate; AA407280; Bars; BARS-50; brefeldin A-ADP-riboslyated substrate; brefeldin A-ribosylated substrate; CTBP; Ctbp1; CtBP1-L; CtBP1-S; CTBP2; Ctbp3; CtBP3/BARS; C-terminal binding protein 1; C-terminal binding protein 2; C-terminal-binding protein 1; C-terminal-binding protein 2; C-terminal-binding protein 3; C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate; D4S115h; D5H4S115; D5H4S115E; D7Ertd45e; gene trap ROSA b-geo 6; Gtrgeo6; ribeye
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13016, 13017, 1487, 1488, 29382, 81717
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: O88712, P56545, P56546, Q13363, Q9EQH5, Q9Z2F5
Gene Symbols: CTBP1, CTBP2
Immunogen: A synthesized peptide derived from human CTBP1(Accession Q13363), corresponding to amino acid residues T132-L182.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CtBP1/CtBP2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CTBP2
Gene Alias:
50 kDa BFA-dependent ADP-ribosylation substrate; 50-kDa BFA-induced ADP-ribosylated substrate; 50-kDaBFA-inducedADP-ribosylatedsubstrate; AA407280; Bars; BARS-50; brefeldin A-ADP-riboslyated substrate; brefeldin A-ribosylated substrate; CTBP; Ctbp1; CtBP1-L; CtBP1-S; CTBP2; Ctbp3; CtBP3/BARS; C-terminal binding protein 1; C-terminal binding protein 2; C-terminal-binding protein 1; C-terminal-binding protein 2; C-terminal-binding protein 3; C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate; D4S115h; D5H4S115; D5H4S115E; D7Ertd45e; gene trap ROSA b-geo 6; Gtrgeo6; ribeye
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13016, 13017, 1487, 1488, 29382, 81717
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
O88712, P56545, P56546, Q13363, Q9EQH5, Q9Z2F5
Gene Symbols:
CTBP1, CTBP2
Immunogen:
A synthesized peptide derived from human CTBP1(Accession Q13363), corresponding to amino acid residues T132-L182.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG