PIPA5106932

PLAT Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA5106932-Each-of-1 In Stock ₹ 44,705.10

PIPA5106932 - Each of 1

₹ 44,705.10

In Stock

Quantity

1

Base Price: ₹ 44,705.10

GST (18%): ₹ 8,046.918

Total Price: ₹ 52,752.018

Antigen

PLAT

Classification

Polyclonal

Conjugate

Unconjugated

Gene

PLAT

Gene Alias

3.4.21.68; Alteplase; AU020998; AW212668; D8Ertd2e; PATISS; plasminogen activator, tissue; plasminogen activator, tissue type; plasminogen/activator kringle; PLAT; Reteplase; serine protease; t plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; TPA; t-PA; t-plasminogen activator

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

18791, 25692, 5327

Content And Storage

-20°C

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.

P00750, P11214, P19637

Gene Symbols

PLAT

Immunogen

A synthesized peptide derived from human PLAT(Accession P00750), corresponding to amino acid residues L446-T496.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • Antibody detects endogenous levels of total PLAT
  • TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen
  • By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physio pathological events
  • It specifically cleaves the Arg- -Val bond in plasminogen to form plasmin, and is comprised of a heterodimer of chain A and chain B held by a disulfide bond
  • TPA binds to fibrin with high affinity
  • This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-and 1000-fold, due to an increase in affinity for plasminogen
  • Similarly, binding to heparin increases the activation of plasminogen
  • Binding to laminin and fibronectin has also been demonstrated
  • TPA also binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1)
  • These proteins are involved in TPA clearance
  • TPA binds to annexin II and to cytokeratin 8
  • As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation
  • In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA5106932

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Antigen:
PLAT

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
PLAT

Gene Alias:
3.4.21.68; Alteplase; AU020998; AW212668; D8Ertd2e; PATISS; plasminogen activator, tissue; plasminogen activator, tissue type; plasminogen/activator kringle; PLAT; Reteplase; serine protease; t plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; TPA; t-PA; t-plasminogen activator

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
18791, 25692, 5327

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P00750, P11214, P19637

Gene Symbols:
PLAT

Immunogen:
A synthesized peptide derived from human PLAT(Accession P00750), corresponding to amino acid residues L446-T496.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5106933

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Antigen:
Ephrin B2

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Efnb2

Gene Alias:
EFNB2; efnb2a; Elf2; ELF-2; EPH-related receptor tyrosine kinase ligand 5; ephrin B2; ephrin B2a; ephrin-B2; Ephrin-B2a; Epl5; EPLG5; HTK ligand; Htkl; HTK-L; id:ibd5072; Lerk5; LERK-5; ligand of eph-related kinase 5; MGC126226; MGC126227; MGC126228; NLERK-1

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
13642, 1948, 306636

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P52799, P52800

Gene Symbols:
Efnb2

Immunogen:
A synthesized peptide derived from human EFNB2(Accession P52799), corresponding to amino acid residues Y304-V333.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5106934

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Antigen:
Substance P

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
TAC1

Gene Alias:
4930528L02Rik; C-terminal-flanking peptide; Hs.2563; MGC26719; neurokinin 1; neurokinin 2; neurokinin A; neurokinin alpha; neuromedin L; Neuropeptide gamma; neuropeptide K; NK1; NK-1; NK2; Nka; Nkna; NPK; PPT; Ppt5fl; PPTA; PPT-A; PPTA3; precursor 1; preprotachykinin; preprotachykinin A; protachykinin; protachykinin-1; RAT TAC; RATPPTA3; SP; substance K; Substance P; TAC; Tac1; TAC2; Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma); tachykinin 1; tachykinin 2; tachykinin precursor 1; tachykinin, precursor 1; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
21333, 24806, 6863

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P06767, P20366, P41539

Gene Symbols:
TAC1

Immunogen:
A synthesized peptide derived from human TAC1(Accession P20366), corresponding to amino acid residues D38-Y88.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5106935

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Antigen:
DAP

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
DAP

Gene Alias:
4921531N22Rik; AI789753; amylin peptide; AU040360; DAP; DAP 1; DAP1; DAP-1; death associated protein; death-associated protein; death-associated protein 1; MGC99796; OTTHUMP00000161670; OTTHUMP00000221331; Rap7a

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
1611, 223453, 64322

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P51397, Q91XC8, Q9QX67

Gene Symbols:
DAP

Immunogen:
A synthesized peptide derived from human DAP(Accession P51397), corresponding to amino acid residues M1-K37.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG