beta-2 Defensin Polyclonal Antibody, Invitrogen™

Description

• Product is supplied at 1 mL (100 μL/mL)
• Application Notes: Western Blot - Test was performend under reduced sample treatment using SDS-Page
• The band size is 25kDa for recombinant protein with tag and 5 kDa for the native protein
• IHC-P- Tissue sections were pretreated with high temperature citrate and fixed in formalin
• PBS was used as a negative control
• Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system
• The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds
• To date, six human beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6
• beta-defensins are expressed on some leukocytes and at epithelial surfaces
• In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells
• The beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence
• Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.